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首页> 外文期刊>Neuropsychology >Traumatic Brain Injury History Is Associated With an Earlier Age of Dementia Onset in Autopsy-Confirmed Alzheimer's Disease
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Traumatic Brain Injury History Is Associated With an Earlier Age of Dementia Onset in Autopsy-Confirmed Alzheimer's Disease

机译：创伤性脑损伤史与尸检患者患者患者患者患者证实的Alzheimer疾病有关

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Objective: To evaluate whether a history of traumatic brain injury (TBI) with reported loss of consciousness (LOC) is a risk factor for earlier onset of Alzheimer's disease (AD) in an autopsy-confirmed sample. Method: Data from 2,133 participants with autopsy-confirmed AD (i.e., at least Braak neurofibrillary tangle stages III to VI and CERAD neuritic plaque score moderate to frequent) were obtained from the National Alzheimer's Coordinating Center (NACC). Participants were categorized by presence/absence of self-reported remote (i.e., 1 year prior to their first Alzheimer's Disease Center visit) history of TBI with LOC (TBI+ vs. TBI-). Analyses of Covariance (ANCOVA) controlling for sex, education, and race compared groups on clinician-estimated age of symptom onset and age of diagnosis. Results: Average age of onset was 2.34 years earlier (p = .01) for the TBI+ group (n = 194) versus the TBI+ group (n = 1900). Dementia was diagnosed on average 2.83 years earlier (p = .002) in the TBI+ group (n = 197) versus the TBI+ group (n = 1936). Using more stringent neuropathological criteria (i.e., Braak stages V-VI and CERAD frequent), both age of AD onset and diagnosis were 3.6 years earlier in the TBI+ group (both p's .001). Conclusions: History of TBI with reported LOC appears to be a risk factor for earlier AD onset. This is the first study to use autopsy-confirmed cases, supporting previous investigations that used clinical criteria for the diagnosis of AD. Further investigation as to possible underlying mechanisms of association is needed.
机译：目的：评价是否具有报告意识丧失（LOC）的创伤性脑损伤（TBI）的历史是阿尔茨海默病（AD）在尸检确认的样品中的危险因素。方法：来自国家阿尔茨海默氏症的协调中心（NACC）获得了来自尸检确认的AD的2,133名参与者的数据（即至少Braak神经纤维斑点III至VI和Cerad神经炎斑块分数中等至频繁）。参与者被自我报告的偏远（即，第一次阿尔茨海默病中心前1年）的存在/不存在分类，其中TBI的历史与LOC（TBI +与TBI-）。对性别，教育和种族的协方差（ANCOVA）的分析与诊所症状估计症状估计年龄和诊断年龄的组织。结果：TBI +组的平均发作年龄为234年（p = .01）（n = 194）与TBI +组（n = 1900）。痴呆症平均诊断为2.83年之前（P = .002）在TBI +组（n = 197）与TBI +组（n = 1936）中。使用更严格的神经病理学标准（即，Braak Stages V-Vi和Cerad频繁），TBI +组（P的诊断）的年龄增长和诊断为3.6年（P's＆ .001）。结论：据报道，TBI的历史似乎是早期广告发病的危险因素。这是第一次使用尸检证实案件的研究，支持先前的调查，这些调查使用临床标准进行广告的诊断。需要对可能的关联潜在机制进行进一步调查。

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