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首页> 外文期刊>Neuropsychology >A Meta-Analysis of Inhibitory-Control Deficits in Patients Diagnosed With Alzheimer's Dementia
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A Meta-Analysis of Inhibitory-Control Deficits in Patients Diagnosed With Alzheimer's Dementia

机译：患有阿尔茨海默痴呆症患者的抑制性控制缺陷的荟萃分析

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Objective: The authors conducted meta-analyses to determine the magnitude of performance impairments in patients diagnosed with Alzheimer's dementia (AD) compared with healthy aging (HA) controls on eight tasks commonly used to measure inhibitory control. Method: Response time (RT) and error rates from a total of 64 studies were analyzed with random-effects models (overall effects) and mixed-effects models (moderator analyses). Results: Large differences between AD patients and HA controls emerged in the basic inhibition conditions of many of the tasks with AD patients often performing slower, overall d = 1.17, 95% CI [0.88-1.45], and making more errors, d = 0.83 [0.63-1.03]. However, comparably large differences were also present in performance on many of the baseline control-conditions, d = 1.01 [0.83-1.19] for RTs and d = 0.44 [0.19-0.69] for error rates. A standardized derived inhibition score (i.e., control-condition score-inhibition-condition score) suggested no significant mean group difference for RTs, d = -0.07 [-0.22-0.08], and only a small difference for errors, d = 0.24 [-0.12-0.60]. Effects systematically varied across tasks and with AD severity. Conclusions: Although the error rate results suggest a specific deterioration of inhibitory-control abilities in AD, further processes beyond inhibitory control (e.g., a general reduction in processing speed and other, task-specific attentional processes) appear to contribute to AD patients' performance deficits observed on a variety of inhibitory-control tasks. Nonetheless, the inhibition conditions of many of these tasks well discriminate between AD patients and HA controls.
机译：目的：作者进行了荟萃分析，以确定患有阿尔茨海默痴呆症（AD）的患者的性能障碍程度，与健康老化（HA）对照有常用于测量抑制控制的八个任务。方法：通过随机效应模型（总体效应）和混合效果模型（主持人分析）分析了总共64项研究的响应时间（RT）和错误率。结果：AD患者的巨大差异和AD患者许多任务的基本抑制条件下的差异往往往往表现较慢，总体D = 1.17，95％CI [0.88-1.45]，并制作更多误差，d = 0.83 [0.63-1.03]。然而，在许多基线控制条件下，对于RTS和D = 0.44 [0.19-0.69]的许多基线控制条件，对于许多基线控制条件，也存在较大的差异。标准化的衍生抑制得分（即，控制条件得分抑制条件得分）表明RTS的显着平均群体差异，d = -0.07 [-0.22-0.08]，并且只有误差差异，d = 0.24 [ -0.12-0.60]。效果在系统地跨任务和广告严重性变化。结论：虽然错误率结果表明AD中抑制控制能力的特定恶化，但是超越抑制控制的进一步处理（例如，加工速度和其他，任务特定的注意过程的一般降低）似乎有助于广告患者的表现在各种抑制控制任务上观察到的缺陷。尽管如此，许多这些任务的抑制条件很好地区分AD患者和HA控制。

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