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首页> 外文期刊>Materials science & engineering, C. Materials for Biogical applications >An exploratory study of articular cartilage and subchondral bone reconstruction with bone marrow mesenchymal stem cells combined with porous tantalum/Bio-Gide collagen membrane in osteonecrosis of the femoral head
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An exploratory study of articular cartilage and subchondral bone reconstruction with bone marrow mesenchymal stem cells combined with porous tantalum/Bio-Gide collagen membrane in osteonecrosis of the femoral head

机译：骨髓间充质干细胞与多孔钽/生物胶原膜结合股骨头骨折的骨髓间充质干细胞和骨髓间充质骨骼重建的探索性研究

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摘要

Osteonecrosis of the femoral head (ONFH) results in collapse of the femoral head and rapid destruction of the hip joint. The repair of post-collapse articular cartilage and subchondral bone is challenging. We interrupted the blood supply to the femoral head and established a full-thickness articular defect animal model after ONFH was determined via X-ray. Porous tantalum and a Bio-Gide collagen membrane, co-cultured with bone marrow mesenchymal stem cells (BMSCs) in vitro, were implanted into the defect zone to repair the full-thickness articular defect. Hyaline cartilage was detected on top of the tantalum near the edge of the defect 12 weeks post-operatively. Porous tantalum and a Bio-Gide collagen membrane with BMSCs may repair full-thickness articular defects if the blood supply can be reconstructed in the post-collapse stage of ONFH.
机译：股骨头的骨折（ONFH）导致股骨头的塌陷，髋关节快速破坏。 修复崩溃后关节软骨和副骨头骨头是挑战性的。 我们中断股骨头的血液供应，并在通过X射线确定ONFH后建立了全厚的关节缺陷动物模型。 在体外用骨髓间充质干细胞（BMSCs）共同培养的多孔钽和生物胶质胶原膜，植入缺陷区以修复全厚的关节缺陷。 在可操作地后12周的缺陷边缘附近垂直于钽的顶部检测到透明软骨。 多孔钽和BMSC的生物型胶原膜可以修复全厚关节缺陷，如果血液供应可以在ONFH的崩溃阶段重建。

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