Doxorubicin eluting microporous polysaccharide scaffolds: An implantable device to expunge tumour

Preethi G. U.; Sreekutty J.; Unnikrishnan B. S.; Archana M. G.; Syama H. P.; Deepa Mohan; Shiji R.; Anusree K. S.; Sreelekha T. T.

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Doxorubicin eluting microporous polysaccharide scaffolds: An implantable device to expunge tumour

机译：多柔比星洗脱微孔多糖脚手架：一种植入装置，用于曝光肿瘤

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A variety of naturally derived and synthetic biomaterial scaffolds have been investigated as 3D environments for supporting cell growth and can be used to achieve drug delivery with high loading efficiency. Polysaccharides which enhance the tumour-specific drug release are ideal candidates for scaffold preparation in combination with chemotherapeutic agents for the management of solid tumours by local applications. Galactoxyloglucan (PST001) based porous scaffolds (PS) were prepared by crosslinking and freeze drying with a porosity of 90%. FTIR showed the same functional groups as of PST001 with slight peak shifts and 1200% water absorption was observed. Comparing with PBS, macrophage mediated improved degradation up to 40% in 28 days was observed. The scaffold was relatively non toxic towards normal and cancer cells and there was no epithelial mesenchymal transition (EMT) observed. In vitro drug release profile of doxorubicin (DOX)-loaded scaffold (PSD) showed higher release at acidic pH, apparent in tumour microenvironment, than normal physiological pH. In in vitro assays, cell viability was decreased confirming the drug release potential of the scaffold. DLA tumour was significantly reduced with PSD implantation. The excellent biodegradability of the PS overcome the limitations of non-biodegradable systems which support the sustained release of the drug and degrade after a specific time period. The local tumour reduction potential of the PSD embrace immense application in malignant solid tumour management.

机译：已经研究了各种天然衍生的和合成的生物材料支架作为用于支持细胞生长的3D环境，并且可用于实现高负载效率的药物递送。增强肿瘤特异性药物释放的多糖是支架制剂的理想候选者，其与局部应用组合使用用于管理实体瘤的化学治疗剂。通过交联并冷冻干燥的孔隙率为90％，制备基于Galactoxyloglucan（PST001）的多孔支架（PS）。 FTIR显示与PST001相同的官能团，具有轻微的峰值偏移，观察到1200％的吸水性。比较PBS，巨噬细胞介导的改善降解在28天内高达40％。支架对正常和癌细胞相对无毒，并且没有观察到上皮间充质转换（EMT）。在多柔比星（DOX）的体外药物释放曲线 - 载荷的支架（PSD）在酸性pH下显示出更高的释放，在肿瘤微环境中明显，比正常的生理pH值。在体外测定中，降低细胞活力证实支架的药物释放电位。用PSD植入显着降低DLA肿瘤。 PS的优异生物降解性克服了支持药物持续释放的非生物降解系统的限制，并在特定时间段内降解。 PSD的局部肿瘤降低潜力在恶性实体肿瘤管理中拥抱巨大应用。

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《Materials science & engineering, C. Materials for Biogical applications》 |2020年第2020期|共12页
作者
Preethi G. U.; Sreekutty J.; Unnikrishnan B. S.; Archana M. G.; Syama H. P.; Deepa Mohan; Shiji R.; Anusree K. S.; Sreelekha T. T.;
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作者单位

Univ Kerala Res Ctr Reg Canc Ctr Div Canc Res Lab Biopharmaceut &

Nanomed Thiruvananthapuram Kerala India;

Univ Kerala Res Ctr Reg Canc Ctr Div Canc Res Lab Biopharmaceut &

Nanomed Thiruvananthapuram Kerala India;

Univ Kerala Res Ctr Reg Canc Ctr Div Canc Res Lab Biopharmaceut &

Nanomed Thiruvananthapuram Kerala India;

Univ Kerala Res Ctr Reg Canc Ctr Div Canc Res Lab Biopharmaceut &

Nanomed Thiruvananthapuram Kerala India;

Univ Kerala Res Ctr Reg Canc Ctr Div Canc Res Lab Biopharmaceut &

Nanomed Thiruvananthapuram Kerala India;

Univ Kerala Res Ctr Reg Canc Ctr Div Canc Res Lab Biopharmaceut &

Nanomed Thiruvananthapuram Kerala India;

Univ Kerala Res Ctr Reg Canc Ctr Div Canc Res Lab Biopharmaceut &

Nanomed Thiruvananthapuram Kerala India;

Univ Kerala Res Ctr Reg Canc Ctr Div Canc Res Lab Biopharmaceut &

Nanomed Thiruvananthapuram Kerala India;

Univ Kerala Res Ctr Reg Canc Ctr Div Canc Res Lab Biopharmaceut &

Nanomed Thiruvananthapuram Kerala India;

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正文语种 eng
中图分类工程材料学;
关键词
Microporous; Scaffolds; Doxorubicin; Tumour; Local implantation;

机译：微孔;脚手架;多柔比星;肿瘤;局部植入;

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专利

1. Doxorubicin eluting microporous polysaccharide scaffolds: An implantable device to expunge tumour [J] . Preethi G. U., Sreekutty J., Unnikrishnan B. S., Materials science & engineering . 2020,第Feba期

机译：阿霉素洗脱微孔多糖支架：一种可植入的清除肿瘤的装置
2. Vasomotor Function Comparative Assessment at 1 and 2 Years Following Implantation of the Absorb Everolimus-Eluting Bioresorbable Vascular Scaffold and the Xience V Everolimus-Eluting Metallic Stent in Porcine Coronary Arteries Insights From In Vivo Angiography, Ex Vivo Assessment, and Gene Analysis at the Stented/Scaffolded Segments and the Proximal and Distal Edges [J] . Gogas Bill D., Benham James J., Hsu Steve, JACC. Cardiovascular interventions . 2016,第7期

机译：从体内血管造影术，活体评估和支架/基因分析获得的猪冠状动脉内植入吸收性依维莫司洗脱生物可吸收性血管支架和Xience V依维莫司洗脱金属支架后1年和2年的血管运动功能比较评估脚手架节段和近端和远端
3. Incidence and Imaging Outcomes of Acute Scaffold Disruption and Late Structural Discontinuity After Implantation of the Absorb Everolimus-Eluting Fully Bioresorbable Vascular Scaffold Optical Coherence Tomography Assessment in the ABSORB Cohort B Trial (A Clinical Evaluation of the Bioabsorbable Everolimus Eluting Coronary Stent System in the Treatment of Patients With De Novo Native Coronary Artery Lesions) [J] . Onuma Yoshinobu, Serruys Patrick W., Muramatsu Takashi, JACC. Cardiovascular interventions . 2014,第12期

机译：吸收性依维莫司洗脱完全生物可吸收的血管支架光学相干断层扫描植入后急性支架破裂和晚期结构不连续的发生率和影像学结果在ABSORB队列B试验中进行评估（生物可吸收性依维莫司洗脱冠状动脉支架系统治疗的临床评估De Novo天然冠状动脉病变患者）
4. Doxorubicin drug eluting beads: Analysis of tissue release in patients with liver tumor [C] . Julien Namur, Steven J Citron, Mark H Dupuis, Annual meeting exposition of the Controlled Release Society . 2009

机译：阿霉素药物洗脱珠：肝肿瘤患者组织释放的分析
5. The distribution of the anti-cancer drug doxorubicin in relation to blood vessels and regions of hypoxia in solid tumours. [D] . Primeau, Andrew J. 2005

机译：抗肿瘤药阿霉素在实体瘤中与血管和缺氧区域有关的分布。
6. Microporous polysaccharide multilayer coated BCP composite scaffolds with immobilised calcitriol promote osteoporotic bone regeneration both in vitro and in vivo: Erratum [O] . Qian Tang, Zhichao Hu, Haiming Jin, 2021

机译：微孔多糖多层涂层BCP复合支架具有固定化的煅烧亚二醇促进体外和体内骨质骨再生：错误
7. Incidence and Imaging Outcomes of Acute Scaffold Disruption and Late Structural Discontinuity After Implantation of the Absorb Everolimus-Eluting Fully Bioresorbable Vascular Scaffold: Optical Coherence Tomography Assessment in the ABSORB Cohort B Trial (A Clinical Evaluation of the Bioabsorbable Everolimus Eluting Coronary Stent System in the Treatment of Patients With De Novo Native Coronary Artery Lesions). [O] . Onuma, Yoshinobu, Serruys, Patrick W, Muramatsu, Takashi, 2014

机译：植入吸收性依维莫司洗脱的完全可生物吸收的血管支架后急性支架破裂和晚期结构不连续的发生率和影像学结果：ABSORB队列B试验中的光学相干断层扫描评估（治疗中可生物吸收的依维莫司洗脱冠状动脉支架系统的临床评估De Noovo天然冠状动脉病变的患者）

Doxorubicin eluting microporous polysaccharide scaffolds: An implantable device to expunge tumour

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