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首页> 外文期刊>Neurosurgical focus >Transcranial MR-guided focused ultrasound sonothrombolysis in the treatment of intracerebral hemorrhage
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Transcranial MR-guided focused ultrasound sonothrombolysis in the treatment of intracerebral hemorrhage

机译：经颅MR引导的聚焦超声腐败脑出血治疗

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摘要

Intracerebral hemorrhage remains a significant cause of morbidity and mortality. Current surgical therapies aim to use a minimally invasive approach to remove as much of theclot as possible without causing undue disruption to surrounding neural structures. Transcranial MR-guided focused ultrasound (MRgFUS) surgery is an emerging technology that permits a highly concentrated focal point of ultrasound energy to be deposited to a target deep within the brain without an incision or craniotomy. With appropriate ultrasound parameters it has been shown that MRgFUS can effectively liquefy large-volume blood clots through the human calvaria. In this review the authors discuss the rationale for using MRgFUS to noninvasively liquefy intracerebral hemorrhage (ICH), thereby permitting minimally invasive aspiration of the liquefied clot via a small drainage tube. The mechanism of action of MRgFUS sonothrombolysis; current investigational work with in vitro, in vivo, and cadaveric models of ICH; and the potential clinical application of this disruptive technology for the treatment of ICH are discussed.
机译：脑出血仍然是发病率和死亡率的显着原因。目前的手术疗法旨在使用微创方法尽可能多地删除尽可能多的仪表，而不会导致周围的神经结构的过度破坏。经颅MR引导的聚焦超声（MRGFUS）手术是一种新兴技术，允许高度浓缩的超声能量焦点沉积在大脑内的靶内而没有切口或颅骨。有适当的超声参数，已经证明MRGFU可以通过人类Calvaria有效地液化大量血栓。在本文中，作者讨论了使用MRGFU以非侵入性液化脑出血（ICH）的理由，从而允许通过小排水管微创的液化凝块的侵入性吸入。 MRGFUS SONOTHROMOMBOLEARY的作用机制;目前的研究与体外，体内和尸体模型的ich;讨论了这种破坏性技术治疗ICH的潜在临床应用。

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