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首页> 外文期刊>Neurosurgical focus >Magnetoencephalographic virtual recording: A novel diagnostic tool for concussion
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Magnetoencephalographic virtual recording: A novel diagnostic tool for concussion

机译：磁力虚拟录音：震荡的新型诊断工具

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摘要

Object: Heightened recognition of the prevalence and significance of head injury in sports and in combat veterans has brought increased attention to the physiological and behavioral consequences of concussion. Current clinical practice is in part dependent on patient self-report as the basis for medical decisions and treatment. Magnetoencephalography (MEG) shows promise in the assessment of the pathophysiological derangements in concussion. The authors have developed anovel MEG-based neuroimaging strategy to provide objective, noninvasive, diagnostic information in neurological disorders. In the current study the authors demonstrate a novel task protocol and then assess MEG virtual recordings obtained during task performance as a diagnostic tool for concussion. Methods: Ten individuals (5 control volunteers and 5 patientswith a history of concussion) were enrolled in this pilot study. All participants underwent an MEG evaluation during performance of a language/spatial task. Each individual produced 960 responses to 320 sentence stimuli; 0.3 sec of MEG datafrom each word presentation and each response were analyzed: the data from each participant were classified using a ruleconstructed from the data obtained from the other 9 participants. Results: Analysis of response times showed significantdifferences (p 10-4) between concussed and normal groups, demonstrating the sensitivity of the task. The MEG measures enabled the correct classification of 8 of 10 individuals as concussed versus nonconcussed (p = 0.055). Analysis ofsingle-trial data classified 70% of trials correctly (p 10-10). Concussed patients showed increased activation in theoccipitoparietal and temporal regions during evaluation. Conclusions: These pilot findings are the first evidence of the utility of MEG virtual recording in diagnosing concussion. With further refinements, MEG virtual recordings may represent a noninvasive test to diagnose concussion and monitor its resolution.
机译：对象：对体育和战斗力士的头部损伤的患病率和显着性提高了识别，从而提高了脑震荡的生理和行为后果。目前的临床实践部分依赖于患者自我报告作为医学决策和治疗的基础。磁性脑图（MEG）在评估脑震荡中评估病理生理紊乱的情况下显示了承诺。作者开发了基于ANOVEL的神经影像学策略，提供了神经系统疾病的客观，非侵入性诊断信息。在目前的研究中，作者演示了一种新颖的任务协议，然后评估任务性能中获得的MEG虚拟录像作为脑震荡的诊断工具。方法：在这项试点研究中注册了十名个人（5个控制志愿者和5名脑震荡历史）。所有参与者在语言/空间任务的绩效期间接受了MEG评估。每个人都产生960次判断刺激的回应;分析了0.3秒的MEG DataFrom每个单词演示和每个响应：每个参与者的数据使用从其他9名参与者获得的数据中的覆盖范围分类。结果：响应时间分析显示焦急和正常组之间的显着性（P <10-4），展示了任务的敏感性。 MEG措施使10个以10个个人的正确分类为令人焦虑而不是非协调（P = 0.055）。分析 - 试验数据正确分类70％的试验（P <10-10）。展示患者在评估期间表现出在occiparietal和颞区的激活增加。结论：这些导频调查结果是MEG虚拟录音在诊断脑震荡中的第一证据。通过进一步的改进，MEG虚拟录像可能代表非侵入性测试以诊断脑震荡并监控其分辨率。

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  • 来源
    《Neurosurgical focus》 |2012年第6期|共1页
  • 作者

    TormentiM.; KriegerD.; PuccioA.M.; McneilM.R.; SchneiderW.; OkonkwoD.O.;

  • 作者单位

    Departments of Neurological Surgery University of Pittsburgh PA United States;

    Departments of Neurological Surgery University of Pittsburgh PA United States;

    Departments of Neurological Surgery University of Pittsburgh PA United States;

    Departments of Communication Science and Disorders University of Pittsburgh PA United States;

    Departments of Psychology University of Pittsburgh PA United States;

    Departments of Neurological Surgery University of Pittsburgh PA United States;

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  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类 外科学;
  • 关键词

    Concussion; Magnetoencephalography; Mild traumatic brain injury;

    机译：脑震荡;磁性脑图;轻度创伤性脑损伤;

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