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首页> 外文期刊>Neurosurgical focus >Hippocampal and cerebellar atrophy in patients with Cushing’s disease
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Hippocampal and cerebellar atrophy in patients with Cushing’s disease

机译：患者患者的海马和小脑萎缩

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OBJECT Cushing’s disease (CD) may cause atrophy of different regions of the human brain, mostly affecting the hippocampus and the cerebellum. This study evaluates the use of 3-T MRI of newly diagnosed patients with CD to detect atrophic degeneration with voxel-based volumetry. METHODS Subjects with newly diagnosed, untreated CD were included and underwent 3-T MRI. Images were analyzed using a voxelwise statistical test to detect reduction of brain parenchyma. In addition, an atlas-based volumetric study for regions likely to be affected by CD was performed. RESULTS Nineteen patients with a mean disease duration of 24 months were included. Tumor markers included adrenocorticotropic hormone (median 17.5 pmol/L), cortisol (949.4 nmol/L), and dehydroepiandrosterone sulfate (5.4 μmol/L). The following values are expressed as the mean ± SD. The voxelwise statistical test revealed clusters of significantly reduced gray matter in the hippocampus and cerebellum, with volumes of 2.90 ± 0.26 ml (right hippocampus), 2.89 ± 0.28 ml (left hippocampus), 41.95 ± 4.67 ml (right cerebellar hemisphere), and 42.11 ± 4.59 ml (left cerebellar hemisphere). Healthy control volunteers showed volumes of 3.22 ± 0.25 ml for the right hippocampus, 3.23 ± 0.25 ml for the left hippocampus, 50.87 ± 4.23 ml for the right cerebellar hemisphere, and 50.42 ± 3.97 ml for the left cerebellar hemisphere. CONCLUSIONS Patients with untreated CD show significant reduction of gray matter in the cerebellum and hippocampus. These changes can be analyzed and objectified with the quantitative voxel-based method described in this study.
机译：对象缓冲的疾病（CD）可能导致人脑的不同区域的萎缩，主要影响海马和小脑。本研究评估了新诊断的CD患者的3-T MRI以检测基于体素的体积的萎缩变性。方法包括新诊断，未处理的CD的受试者并进行3-T MRI。使用VoxelWise统计测试分析图像以检测脑实质的减少。此外，对可能受Cd的可能影响的区域的基于地图集的体积研究进行。结果包括24个月平均疾病持续时间的19名患者。肿瘤标志物包括肾上腺皮质激素（中位数17.5 pmol / L），皮质醇（949.4 nmol / L）和硫酸脱氢酮（5.4μmol/ L）。以下值表示为平均值±SD。 VoxelWise统计测试揭示了海马和小脑中显着减少灰质的簇，体积为2.90±0.26ml（右海马），2.89±0.28ml（左海马），41.95±4.67ml（右侧小脑半球）和42.11 ±4.59毫升（左脑半球）。健康的控制志愿者右海马的3.22±0.25毫升显示3.22±0.25毫升，左半球的左半球50.87±4.23ml为50.87±4.23ml，左心前半球50.42±3.97ml。结论未处理的CD患者显示出小脑和海马灰质的显着降低。通过本研究中描述的基于量化的基于体素的方法，可以分析和对象进行这些变化。

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