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首页> 外文期刊>BJU international >Skeletal growth and long-term bone turnover after enterocystoplasty in a chronic rat model.
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Skeletal growth and long-term bone turnover after enterocystoplasty in a chronic rat model.

机译：在慢性大鼠模型中，进行肠囊成形术后骨骼生长和长期骨转换。

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OBJECTIVE: To investigate skeletal growth and bone metabolism in a chronic animal model of urinary diversion. MATERIALS AND METHODS: Young male Wistar rats (120) were allocated randomly to four groups undergoing: ileocystoplasty, ileocystoplasty and resection of the ileocaecal segment, colocystoplasty, and controls. All animals received antibiotics for 1 week after surgery; half of each group remained on oral antibiotics. Bone-related biochemistry was measured in serum and urine. Dual-energy X-ray absorptiometry and peripheral quantitative computed tomography (pQCT) were used to determine bone mass ex vivo. RESULTS: Most (90%) of the rats survived the study period (8 months); six rats died from bowel obstruction at the level of the entero-anastomosis and four had to be killed because of persistent severe diarrhoea. Vital intestinal mucosa was found in all augmented bladders. There were no differences in bone length and volume. Loss of bone mass was almost exclusively in rats with ileocystoplasty and resection of the ileocaecal segment (-37.5%, pQCT, P < 0.01). There was no hyperchloraemic metabolic acidosis or gross impairment of renal function. Hypomagnesaemia, hypocalcaemia and decreased insulin-like growth factor-binding protein 3 were the only significant findings on blood analysis. Deoxypyridinoline crosslinks in urine were higher in rats with an enterocystoplasty than in controls. CONCLUSIONS: Enterocystoplasty in rats neither impairs skeletal growth nor bone quantity, but leads to significant loss of bone mass when combined with resection of the ileocaecal segment. Rarefaction of the trabecular network is confined to the metabolically highly active cancellous compartment, most likely as a consequence of intestinal malabsorption.
机译：目的：探讨慢性尿流转移动物模型的骨骼生长和骨骼代谢。材料与方法：将雄性Wistar大鼠（120只）随机分为四组，分别进行回肠膀胱成形术，回肠膀胱成形术和回盲段切除术，同卵裂弹性和对照组。术后1周，所有动物均接受抗生素治疗;每组一半仍口服抗生素。在血清和尿液中测量骨相关的生化指标。双能X线骨密度仪和外周定量计算机断层扫描（pQCT）用于确定离体骨量。结果：大多数（90％）大鼠在研究期（8个月）中存活下来;六只大鼠在肠吻合处死于肠梗阻，而四只则因持续的严重腹泻而被处死。在所有增大的膀胱中均发现了重要的肠粘膜。骨长和骨量无差异。仅有回肠囊成形术和回盲段切除的大鼠的骨量损失几乎全部（-37.5％，pQCT，P <0.01）。没有高氯代谢性酸中毒或肾功能严重受损。低镁血症，低钙血症和胰岛素样生长因子结合蛋白3减少是血液分析的唯一重要发现。肠囊成形术大鼠的尿液中的脱氧吡啶啉交联度高于对照组。结论：大鼠肠囊成形术既不损害骨骼生长也不影响骨量，但是与回盲段切除术相结合时，不会导致骨量的大量损失。小梁网络的反射被限制在代谢活跃的松质区室，这很可能是肠道吸收不良的结果。

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