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首页> 外文期刊>BJU international >Estimation of glomerular filtration rate and bladder capacity: the effect of maturation, ageing, gender and size.
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Estimation of glomerular filtration rate and bladder capacity: the effect of maturation, ageing, gender and size.

机译：肾小球滤过率和膀胱容量的估计：成熟，衰老，性别和大小的影响。

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OBJECTIVE: To show that glomerular filtration rate (GFR) and bladder capacity (BC) develop isometrically, and to provide graphs for estimating GFR and BC for specific individuals of any age, sex, height and weight, for cystometric purposes. MATERIALS AND METHODS: GFR and BC data were collected from published reports; graphs relating GFR and BC to age, sex, height and weight were obtained by using a computerized curve-fitting technique that minimizes the 1.1 power of the absolute error. RESULTS: The plots show the GFR and BC for individuals of 10th, 50th and 90th percentile height and weight as a function of age and sex for different physiological conditions. GFR increases up to age 20 years and thereafter declines, whereas GFR per unit body surface area reaches a maximum at 3.25 years old and declines thereafter. CONCLUSIONS: The clinical management strategy to preserve or enhance renal function in paediatric and adult nephrological disease should incorporate the present data on development, growth, ageing and deterioration of function. These data should be used when interpreting cystometrograms and evaluating compliance. The graphs are useful for clinically estimating GFR and BC, especially when estimating infusion rate and BC for individual patients. BC and GFR develop isometrically with a proportionality constant of 4.56 min, except from birth to 1.5 years of age. Accordingly, individuals with healthy urinary systems, irrespective of age, sex and size, in the same physiological conditions have, on average, the same time to reach BC, ranging from 7 h at a normal 1% GFR to 41 min at the maximum diuresis of 10% GFR.
机译：目的：显示肾小球滤过率（GFR）和膀胱容量（BC）等距发展，并提供用于估算年龄，性别，身高和体重的特定个体的GFR和BC的图表，用于膀胱测量。材料与方法：GFR和BC数据是从已发表的报告中收集的。通过使用最小化绝对误差的1.1幂的计算机化曲线拟合技术，获得了GFR和BC与年龄，性别，身高和体重相关的图表。结果：该图显示了在不同生理条件下，身高和体重分别位于第10、50和90％的个体的GFR和BC随年龄和性别的变化。 GFR会增加到20岁，然后下降，而单位体表面积的GFR在3.25岁时达到最大值，然后下降。结论：在小儿和成人肾病中保存或增强肾脏功能的临床管理策略应纳入有关发育，生长，衰老和功能恶化的现有数据。在解释膀胱造影图和评估依从性时应使用这些数据。该图可用于临床估计GFR和BC，尤其是在估计单个患者的输液速度和BC时。从出生到1.5岁，BC和GFR等轴测图的比例常数为4.56分钟。因此，在相同的生理条件下，具有健康泌尿系统的个体，无论年龄，性别和大小如何，平均都有相同的时间到达BC，范围从正常1％GFR的7小时到最大利尿时间的41分钟10％GFR。

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