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首页> 外文期刊>Nutrition Research >Differential impacts of serum vitamin D levels and age at menarche on metabolic syndrome in premenopausal and postmenopausal women: findings from the Korea national cohort
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Differential impacts of serum vitamin D levels and age at menarche on metabolic syndrome in premenopausal and postmenopausal women: findings from the Korea national cohort

机译：血清维生素D水平和年龄在初期初期初期血清术中初期和绝经后妇女代谢综合征的差异影响：韩国国家队列的调查结果

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It is suggested that vitamin D level and age at menarche are related to each other, and the prevalence of low vitamin D status and early menarche in women is increasing worldwide. Moreover, several studies revealed that both of them are associated with metabolic syndrome (MetS). Therefore, we hypothesized that there are significant associations among vitamin D status, age at menarche, and MetS and that the relationships differ according to menstrual state. We assessed whether the association among MetS, vitamin D, and menarche age is different between premenopausal and postmenopausal women and whether there is a change in risk of MetS according to vitamin D level in different age-at-menarche groups. We used data from the Korea National Health and Nutrition Examination Survey, using 1:1 age-matching for this cross-sectional study. Individuals were stratified into 25-hydroxyvitamin D (25[OH]D) levels (deficient, &10 ng/mL; insufficient, 10-19 ng/mL; and sufficient, &= 20 ng/mL) and categorized as having either early, average, or late menarche (&13,13-16, and &= 17 years). In premenopausal women, early menarche, not vitamin D level, was associated with risk of MetS (odds ratio [95% confidence interval], 1.65 [1.18-2.33]). In contrast, in postmenopausal women, vitamin D deficiency, not age at menarche, was associated with risk of MetS (1.39 [1.03-1.87]). In a stratified analysis regarding interactions of a change in risk of MetS according to vitamin D level in different ages at menarche, vitamin D deficiency was significantly associated with the risk of MetS (1.36 [1.01-1.86]), but this was only in the average-age-at-menarche group. This study suggests that the time of entry into puberty for women may be an important factor in the development of MetS in adulthood, and vitamin D status in women at average menarche age may contribute to the development of MetS. (C) 2018 Elsevier Inc. All rights reserved.
机译：建议初期的维生素D水平和年龄相互关联，妇女低低维生素D状态和早期初潮的患病率在全世界增加。此外，若干研究表明，它们两者与代谢综合征（METS）有关。因此，我们假设维生素D状态有重大关联，月经初期的年龄，并且达到的年龄，并且关系根据月经状态而不同。我们评估了Mets，维生素D和月经初期年龄的关联是否在前进和绝经后妇女之间不同，以及是否存在根据不同年龄初始组的维生素D水平的Mets风险的变化。我们使用来自韩国国家健康和营养考试调查的数据，使用1：1年龄匹配对此横断面研究。个体分层分层成25-羟基维生素D（25 [OH] D）水平（缺乏，＆amp; 10ng / ml;不足，10-19ng / ml;和足够的，＆amp; = 20 ng / ml）并分类为具有早期，平均或晚期初始初潮（＆amp; 13,13-16和＆amp; = 17年）。在前肢女性中，早期月卷，不是维生素D水平，与MET的风险有关（赔率比率[95％置信区间]，1.65 [1.18-2.33]）。相比之下，在绝经后妇女中，维生素D缺乏症，而不是月经初潮的年龄，与MET的风险有关（1.39 [1.03-1.87]）。在有关Mets风险变化的相互作用的分层分析中，根据淫荡的不同年龄的维生素D水平，维生素D缺乏与Mets的风险显着相关（1.36 [1.01-1.86]），但这只是在平均初期初期组织。本研究表明，进入女性青春期的时间可能是在成年期开发的重要因素，平均月初期妇女的维生素D状况可能导致大都会的发展。 （c）2018年Elsevier Inc.保留所有权利。

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