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Porous silicon nanomaterials: recent advances in surface engineering for controlled drug-delivery applications

机译:多孔硅纳米材料:对受控药物输送应用的表面工程最近的进展

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摘要

Porous silicon (pSi) nanomaterials are increasingly attractive for biomedical applications due to their promising properties such as simple and feasible fabrication procedures, tunable morphology, versatile surface modification routes, biocompatibility and biodegradability. This review focuses on recent advances in surface modification of pSi for controlled drug delivery applications. A range of functionalization strategies and fabrication methods for pSi-polymer hybrids are summarized. Surface engineering solutions such as stimuli-responsive polymer grafting, stealth coatings and active targeting modifications are highlighted as examples to demonstrate what can be achieved. Finally, the current status of engineered pSi nanomaterials for in vivo applications is reviewed and future prospects and challenges in drug-delivery applications are discussed.
机译:由于其具有简单和可行的制造程序,可调谐形态,通用表面改性路线,生物相容性和生物降解性,因此,多孔硅(PSI)纳米材料对生物医学应用越来越有吸引力。 本综述重点是对受控药物递送应用的PSI表面改性的最近进展。 总结了一系列官能化策略和用于PSI-聚合物杂交种的制造方法。 突出显示诸如刺激响应聚合物接枝,隐形涂层和活性靶向修改的表面工程解决方案作为示例,以证明可以实现的内容。 最后,讨论了体内应用的工程化PSI纳米材料的当前状态,并讨论了药物交付应用中的未来前景和挑战。

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