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首页> 外文期刊>Lab on a chip >Immature dendritic cells navigate microscopic mazes to find tumor cells
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Immature dendritic cells navigate microscopic mazes to find tumor cells

机译：未成熟的树突细胞导航微观迷宫以找到肿瘤细胞

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摘要

Dendritic cells (DCs) are potent antigen-presenting cells with high sentinel ability to scan their neighborhood and to initiate an adaptive immune response. Whereas chemotactic migration of mature DCs (mDCs) towards lymph nodes is relatively well documented, the migratory behavior of immature DCs (imDCs) in tumor microenvironments is still poorly understood. Here, microfluidic systems of various geometries, including mazes, are used to investigate how the physical and chemical microenvironment influences the migration pattern of imDCs. Under proper degree of confinement, the imDCs are preferentially recruited towards cancer vs. normal cells, accompanied by increased cell speed and persistence. Furthermore, a systematic screen of cytokines, reveals that Gas6 is a major chemokine responsible for the chemotactic preference. These results and the accompanying theoretical model suggest that imDC migration in complex tissue environments is tuned by a proper balance between the strength of the chemical gradients and the degree of spatial confinement.
机译：树突状细胞（DCS）是具有高哨兵能够扫描其邻域的高效抗原呈递细胞并引发适应性免疫应答。虽然成熟DCS（MDC）朝向淋巴结的趋化性迁移相对良好，但肿瘤微环境中未成熟的DCS（IMDC）的迁移行为仍然很差。这里，各种几何形状的微流体系统，包括咪血，探讨了物理和化学微环境如何影响IMDC的迁移模式。在适当的禁闭度下，IMDC优先募集对癌症与正常细胞，伴随着增加的细胞速度和持续性。此外，细胞因子的系统筛网表明，Gas6是负责趋化性偏好的主要趋化因子。这些结果和附带的理论模型表明，在复杂组织环境中的IMDC迁移通过化学梯度强度与空间限制程度之间的适当平衡来调整。

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