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Self-sufficient, low-cost microfluidic pumps utilising reinforced balloons

机译：自给自足，低成本的微流体泵利用加强的气球

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摘要

Here, we introduce a simple method for increasing the inflation pressure of self-sufficient pressure pumps made of latex balloons. Our method involves reinforcing the latex balloon with elastane fibres to restrict the expansion of the balloon and increase its inflation pressure. This allowed us to increase the operational inflation pressure of a latex balloon from 2.5 to 25 kPa. Proof-of-concept experiments show the suitability of the reinforced balloon for inducing lateral forces and recirculating flows, which are employed for hydrodynamic capturing of large human monocytes. We also demonstrate the ability for the rapid exchange of solutions in repeated cycles upon manual squeezing of the reinforced balloons. We also show the suitability of the reinforced balloon for studying the mechanobiology of human aortic endothelial cells under various shear stress levels. The simplicity, portability, affordability, hyper-elasticity and scalability of the reinforced balloon pumps make them suitable for a wide range of microfluidic applications.
机译：在这里，我们介绍了一种简单的方法，用于增加由乳胶气球制成的自足压力泵的充气压力。我们的方法涉及用弹性纤维加固乳胶球囊，以限制球囊的膨胀并增加其充气压力。这使我们可以将乳胶气球的操作充气压力从2.5％到25 kPa增加。概念证据实验表明了增强球囊诱导横向力和再循环流动的适用性，其用于大型人单核细胞的流体动力学捕获。我们还展示了在手动挤压加强的气球时展示在重复循环中快速交换解决方案的能力。我们还展示了增强气球在各种剪切应力水平下研究人主动脉内皮细胞力学学的适用性。增强气囊泵的简单性，便携性，负担能力，超弹性和可扩展性使其适用于各种微流体应用。

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