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首页> 外文期刊>Lab on a chip >Digital microfluidics and nuclear magnetic resonance spectroscopy for in situ diffusion measurements and reaction monitoring
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Digital microfluidics and nuclear magnetic resonance spectroscopy for in situ diffusion measurements and reaction monitoring

机译：数字微流体和核磁共振光谱，用于原位扩散测量和反应监测

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摘要

In recent years microcoils and related structures have been developed to increase the mass sensitivity of nuclear magnetic resonance spectroscopy, allowing this extremely powerful analytical technique to be extended to small sample volumes (5 l). In general, microchannels have been used to deliver the samples of interest to these microcoils; however, these systems tend to have large dead volumes and require more complex fluidic connections. Here, we introduce a two-plate digital microfluidic (DMF) strategy to interface small-volume samples with NMR microcoils. In this system, a planar microcoil is surrounded by a copper plane that serves as the counter-electrode for the digital microfluidic device, allowing for precise control of droplet position and shape. This feature allows for the user-determination of the orientation of droplets relative to the main axes of the shim stack, permitting improved shimming and a more homogeneous magnetic field inside the droplet below the microcoil, which leads to improved spectral lineshape. This, along with high-fidelity droplet actuation, allows for rapid shimming strategies (developed over decades for vertically oriented NMR tubes) to be employed, permitting the determination of reaction-product diffusion coefficients as well as quantitative monitoring of reactive intermediates. We propose that this system paves the way for new and exciting applications for in situ analysis of small samples by NMR spectroscopy.
机译：近年来，已经开发了微梳子和相关结构以增加核磁共振光谱的质量敏感性，从而使这种极其强大的分析技术延伸到小样品体积（＆; 5L）。通常，微通道已被用于将目的样品提供给这些微罩;然而，这些系统倾向于具有大的死量并且需要更复杂的流体连接。在这里，我们介绍了一种双板数字微流体（DMF）策略，以通过NMR微膜接口小体积样品。在该系统中，平面微罩被用作数字微流体装置的反电极的铜平面围绕，允许精确控制液滴位置和形状。该特征允许用户确定液滴相对于垫片堆叠的主轴的方向，允许改进的闪光和微罩下方的液滴内的更加均匀的磁场，这导致改进的光谱线φ。这以及高保真液滴致动，允许采用快速遮光策略（几十年来用于垂直取向的NMR管），允许测定反应 - 产物扩散系数以及反应性中间体的定量监测。我们建议该系统为NMR光谱法对小型样品的原位分析铺平了新的和令人兴奋的应用。

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