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首页> 外文期刊>Lab on a chip >Particle/cell separation using sheath-free deterministic lateral displacement arrays with inertially focused single straight input
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Particle/cell separation using sheath-free deterministic lateral displacement arrays with inertially focused single straight input

机译：使用无鞘的确定性横向位移阵列进行颗粒/电池分离，具有惯于聚焦的单直输入

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摘要

This paper proposes microfluidic particle separation by sheath-free deterministic lateral displacement (DLD) with inertial focusing in a single straight input channel. Unlike conventional DLD devices for size-based particle separation, in which sheath streams are used to focus the particles before the solution containing them reaches the DLD arrays, the proposed method uses inertial focusing to align the particles along the middle or the sidewalls of the straight rectangular input channel. The two-stage model of inertial focusing is applied to reduce the length of the side-focusing channel. The proposed method is demonstrated by using it to separate fluorescent polymer particles of diameters 13 and 7 mu m, in the process of which the effect of the particle focusing regime on the separation performance is also investigated. Through middle focusing, the method is further used to separate MCF-7 cells (a model of circulating tumor cells (CTCs)) and blood cells, with similar to 99.0% capture efficiency achieved.
机译：本文提出了通过在单个直输入通道中具有惯性聚焦的无鞘确定性横向位移（DLD）的微流体颗粒分离。与用于尺寸的粒子分离的传统DLD装置不同，其中使用鞘流在含有达到DLD阵列的溶液之前将颗粒聚焦，所以所提出的方法使用惯性聚焦沿着中间或侧壁对准颗粒或侧壁的侧壁矩形输入通道。应用惯性聚焦的两级模型以减小侧对焦通道的长度。通过使用它以分离直径13和7μm的荧光聚合物颗粒来证明所提出的方法，在该方法中还研究了粒子聚焦方案对分离性能的效果。通过中间聚焦，该方法还用于分离MCF-7细胞（循环肿瘤细胞（CTCS））和血细胞的模型，达到99.0％的捕获效率。

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