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首页> 外文期刊>BJOG: an international journal of obstetrics and gynaecology >Perinatal vertical transmission of antibiotic-resistant bacteria: A systematic review and proposed research strategy
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Perinatal vertical transmission of antibiotic-resistant bacteria: A systematic review and proposed research strategy

机译：围产期抗生素耐药性细菌的垂直传播：系统评价和拟议的研究策略

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Background Antibiotic-resistant bacteria contribute to both early- and late-onset sepsis and outbreaks in neonatal intensive care units (NICUs). The extent to which vertical transmission of these resistant bacteria contributes to colonisation or infection of vulnerable infants in NICUs is unclear. Risk factors for vertical transmission of antibiotic-resistant bacteria are not well described. Objectives To identify studies describing vertical transmission of antibiotic-resistant bacteria, risk factors for transmission and the impact of colonisation on neonatal outcomes. Search strategy EMBASE, CINAHL, Cochrane, PubMed, and MEDLINE databases were searched using selected terminology. Titles and abstracts were screened by two reviewers. Selected papers were reviewed in full by two individuals to ascertain whether they fulfilled the inclusion criteria. Selection criteria Any original article investigating perinatal vertical transmission of antibiotic-resistant bacteria between a mother and neonate was included. Data collection and analysis Data were extracted on study design, organism, antibiotic resistance, and means of ascertaining vertical transmission. Main results Five papers out of 4839 titles fulfilled the inclusion criteria. Four studies were predominantly observational and one was a case report. Each demonstrated perinatal transmission. No study reported risk factors for the transmission of resistant bacteria or the impact of colonisation on neonatal outcomes. Author's conclusions There is an absence of research into the perinatal transmission of resistant organisms despite the potential implications of such a situation. We outline objectives that need to be addressed in future research and describe a study design to ascertain the prevalence and risk factors for vertical transmission.
机译：背景抗生素抗药性细菌会导致新生儿重症监护病房（NICU）的早发性败血症和晚期发作。这些抗性细菌的垂直传播在新生儿重症监护病房中易感婴儿定植或感染的程度尚不清楚。耐药细菌垂直传播的危险因素没有得到很好的描述。目的鉴定描述抗生素抗性细菌的垂直传播，传播的危险因素以及定植对新生儿结局的影响的研究。使用选定的术语搜索EMBASE，CINAHL，Cochrane，PubMed和MEDLINE数据库的搜索策略。标题和摘要由两名审稿人筛选。选定的论文由两个人进行全面审查，以确定他们是否符合纳入标准。选择标准包括任何调查母亲和新生儿之间围生期抗生素耐药性细菌垂直传播的原始文章。数据收集和分析提取有关研究设计，生物，抗生素耐药性和确定垂直传播途径的数据。主要结果4839篇论文中有5篇符合入选标准。四项研究主要是观察性研究，一项是病例报告。每个都显示围产期传播。没有研究报道耐药菌传播或定植对新生儿结局的影响的危险因素。作者的结论尽管存在这种情况的潜在影响，但尚无关于耐药菌围生期传播的研究。我们概述了未来研究中需要解决的目标，并描述了一项研究设计，以确定垂直传播的患病率和风险因素。

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