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首页> 外文期刊>Nitric oxide: Biology and chemistry >The role of gasotransmitters in neonatal physiology
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The role of gasotransmitters in neonatal physiology

机译：汽油转手在新生儿生理学中的作用

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摘要

The gasotransmitters, nitric oxide (NO), hydrogen sulfide (H2S), and carbon monoxide (CO), are endogenously-produced volatile molecules that perform signaling functions throughout the body. In biological tissues, these small, lipid-permeable molecules exist in free gaseous form for only seconds or less, and thus they are ideal for paracrine signaling that can be controlled rapidly by changes in their rates of production or consumption. In addition, tissue concentrations of the gasotransmitters are influenced by fluctuations in the level of O-2 and reactive oxygen species (ROS). The normal transition from fetus to newborn involves a several-fold increase in tissue O-2 tensions and ROS, and requires rapid morphological and functional adaptations to the extrauterine environment. This review summarizes the role of gasotransmitters as it pertains to newborn physiology. Particular focus is given to the vasculature, ventilatory, and gastrointestinal systems, each of which uniquely illustrate the function of gasotransmitters in the birth transition and newborn periods. Moreover, given the relative lack of studies on the role that gasotransmitters play in the newborn, particularly that of H2S and CO, important gaps in knowledge are highlighted throughout the review.
机译：汽油转器，一氧化氮（NO），硫化氢（H 2 S）和一氧化碳（CO）是内源性产生的挥发性分子，其在整个体内进行信号传导功能。在生物组织中，这些小的脂质渗透性分子以自由的气态形式存在于仅几秒钟或更小的情况下，因此它们是可以通过其生产或消费率的变化迅速控制的旁静脉信号传导的理想选择。此外，气体转化器的组织浓度受O-2和反应性氧（ROS）水平的波动的影响。从胎儿到新生儿的正常过渡涉及组织O-2张力和RO的几倍增加，并且需要快速的形态和功能适应于素路环境。本综述总结了汽油转运的作用，因为它与新生生理学相关。特别焦点对脉管系统，透气和胃肠系统，每个胃肠系统唯一地说明了出生过渡和新生儿时期的气体转化器的功能。此外，鉴于对新生儿在新生儿的发挥作用的相对缺乏研究，特别是H2S和CO的作用，在整个审查中都突出了知识中的重要差距。

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