Efficient One-pot Synthesis of alpha-Alkylated beta-Ketothioesters from H2SO4-Catalyzed Tandem Alkylation/Hydrolysis Reaction of Acyclic alpha-Oxo Ketene Dithioacetals with Alcohols

Bai Diangang; Yu Haifeng; Diao Quanping; Li Tiechun

首页> 外文期刊>Letters in organic chemistry >Efficient One-pot Synthesis of alpha-Alkylated beta-Ketothioesters from H2SO4-Catalyzed Tandem Alkylation/Hydrolysis Reaction of Acyclic alpha-Oxo Ketene Dithioacetals with Alcohols

【24h】

Efficient One-pot Synthesis of alpha-Alkylated beta-Ketothioesters from H2SO4-Catalyzed Tandem Alkylation/Hydrolysis Reaction of Acyclic alpha-Oxo Ketene Dithioacetals with Alcohols

机译：从H 2 SO 4催化串联烷基化/水解反应与醇的高效单壶合成α-烷基化β-酮磷酸酯的合成烷基化/水解反应

获取原文

获取原文并翻译 | 示例

掌桥外文数据库（机构版） >>

开具论文收录证明 >>

文献代查 >>

页面导航

摘要
著录项
相似文献
相关主题

摘要

In the paper, we wish to report an efficient one-pot synthesis of alpha-alkylated beta-ketothioesters based on H2SO4-catalyzed tandem alkylation/hydrolysis reaction between acyclic alpha-oxo ketene dithio-acetals and alcohols. It was shown that the tandem reaction could efficiently occur in the presence of 5 mol% H2SO4 at room temperature in CH3CN, affording the desired alpha-alkylated beta-ketothioesters in excellent yields. The use of very small amounts of catalyst, good generality, low cost of the reagents, excellent yield and mild reaction conditions outline the notable features of the reaction.

机译：在本文中，我们希望基于环α-氧代酮二硫代 - 缩醛和醇之间的H 2 SO 4催化串联烷基化/水解反应报告高效的单罐合成α-烷基化β-酮磷酸酯。结果表明，在CH3CN的室温下，可以在5mol％H 2 SO 4存在下有效地发生串联反应，得到所需的α-烷基化β-酮甾体以优异的产率。使用非常少量的催化剂，良好的一般性，低成本的试剂，优异的产率和温和的反应条件概述了反应的显着特征。

著录项

来源
《Letters in organic chemistry》 |2018年第11期|共4页
作者
Bai Diangang; Yu Haifeng; Diao Quanping; Li Tiechun;
展开▼
作者单位

Anshan Normal Univ Sch Chem &

Life Sci Anshan 114007 Liaoning Peoples R China;

Anshan Normal Univ Sch Chem &

Life Sci Anshan 114007 Liaoning Peoples R China;

Anshan Normal Univ Sch Chem &

Life Sci Anshan 114007 Liaoning Peoples R China;

Anshan Normal Univ Sch Chem &

Life Sci Anshan 114007 Liaoning Peoples R China;

展开▼
收录信息
原文格式 PDF
正文语种 eng
中图分类有机化学;
关键词
Thioester; tandem reaction; sulfuric acid; ketene dithioacetal; alcohol; alkylation; hydrolysis;

机译：硫磺酸;串联反应;硫酸;酮二缩醛;醇;烷基化;水解;

相似文献

外文文献
中文文献
专利

1. Efficient One-pot Synthesis of alpha-Alkylated beta-Ketothioesters from H2SO4-Catalyzed Tandem Alkylation/Hydrolysis Reaction of Acyclic alpha-Oxo Ketene Dithioacetals with Alcohols [J] . Bai Diangang, Yu Haifeng, Diao Quanping, Letters in organic chemistry . 2018,第11期

机译：从H 2 SO 4催化串联烷基化/水解反应与醇的高效单壶合成α-烷基化β-酮磷酸酯的合成烷基化/水解反应
2. One-Pot Synthesis of 2,4-Diacyl Thiophenes from alpha-Oxo Ketene Dithioacetals and Propargylic Alcohols [J] . Xue Jian, Bai Li-Gang, Zhang Liang, The Journal of Organic Chemistry . 2020,第15期

机译：从α-氧ketene二缩醛和丙酰基醇的单壶合成2,4-二酰基噻吩和丙酮醇
3. Iododecarboxylation reactions of alpha-oxo ketene dithioacetals: The new route to alpha-iodo ketene dithioacetals [J] . Zhao YL., Liu Q., Sun R., Synthetic Communications . 2004,第3期

机译：α-氧代乙烯酮二硫缩醛的碘脱羧反应：制备α-碘乙烯酮二硫缩醛的新途径
4. One-pot Synthesis of Anthraquinones by Sc(OTf)3-catalyzed Tandem Reaction [C] . Yohei Toriyama, Yoko Yasuno, Tetsuro Shinada 日本化学会春季年会講演予稿集 . 2018

机译：SC（OTF）3催化串联反应的蒽醌合成蒽醌
5. Tandem aza[4+2]/allylboration: A novel multicomponent reaction for the stereocontrolled synthesis of α-hydroxyalkyl piperidine derivatives, and, N,N-diethanolaminomethyl polystyrene: An efficient solid support to immobilize boronic acids [D] . Tailor, Jyotiben M. 2000

机译：串联氮杂[4 + 2] /烯丙基化：α-羟烷基哌啶衍生物和N，N-二乙醇氨基甲基聚苯乙烯的立体控制合成的新型多组分反应：固定硼酸的有效固体载体
6. Expedient one-pot synthesis of indolo32-cisoquinolines via a base-promoted N–alkylation/tandem cyclization [O] . Huy H. Nguyen, James C. Fettinger, Makhluf J. Haddadin, -1

机译：通过碱促进的N-烷基化/串联环化方便地一锅合成吲哚32-c异喹啉
7. Domino Reaction of a-Acetyl-a-carbamoyl Ketene Dithioacetals with Vilsmeier Reagents: A Novel and Efficient Synthesis of 4-Halogenated 2(1H)-Pyridinones [O] . -1

机译：A-乙酰基-A-氨基甲酰基酮二缩醛与Vilsmeier试剂的Domino反应：4-卤化2（1H）的新颖有效合成 - 吡啶酮

Efficient One-pot Synthesis of alpha-Alkylated beta-Ketothioesters from H2SO4-Catalyzed Tandem Alkylation/Hydrolysis Reaction of Acyclic alpha-Oxo Ketene Dithioacetals with Alcohols

摘要

著录项

相似文献

相关主题

期刊订阅