Accumulation of DNA damage and alteration of the DNA damage response in monoclonal B-cell lymphocytosis and chronic lymphocytic leukemia

Henning D. Popp; Johanna Flach; Susanne Brendel

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Accumulation of DNA damage and alteration of the DNA damage response in monoclonal B-cell lymphocytosis and chronic lymphocytic leukemia

机译：单克隆B细胞淋巴细胞症和慢性淋巴细胞白血病中DNA损伤和DNA损伤反应的累积和改变

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Accumulation of DNA damage and alteration of the DNA damage response (DDR) are critical features of genetic instability that is presumed to be implicated in the pathogenesis of monoclonal B-cell lymphocytosis (MBL) and chronic lymphocytic leukemia (CLL).

机译：DNA损伤的积累和DNA损伤响应的变化（DDR）是遗传不稳定的关键特征，这些遗传不稳定被推测涉及单克隆B细胞淋巴细胞症（MBL）和慢性淋巴细胞白血病（CLL）的发病机制。

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《Leukemia and lymphoma》 |2019年第4期|共10页
作者
Henning D. Popp; Johanna Flach; Susanne Brendel;
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Department of Hematology and Oncology Heidelberg University Mannheim Germany;

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正文语种 eng
中图分类肿瘤学;
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1. Accumulation of DNA damage and alteration of the DNA damage response in monoclonal B-cell lymphocytosis and chronic lymphocytic leukemia [J] . Henning D. Popp, Johanna Flach, Susanne Brendel Leukemia and lymphoma . 2019,第3a4期

机译：单克隆B细胞淋巴细胞症和慢性淋巴细胞白血病中DNA损伤和DNA损伤反应的累积和改变
2. DNA damage response-related alterations define the genetic background of patients with chronic lymphocytic leukemia and chromosomal gains [J] . Hernandez-Sanchez Maria, Eugenia Rodriguez-Vicente Ana, Gonzalez-Gascon y Marin Isabel, Experimental Hematology: Official Publication of the International Society for Experimental Hematology . 2019,第期

机译：DNA损伤响应相关的改变定义慢性淋巴细胞白血病和染色体增益的患者的遗传背景
3. Monoclonal B-cell lymphocytosis in individuals from sporadic (non-familial) chronic lymphocytic leukemia families persists over time, but does not progress to chronic B-cell lymphoproliferative diseases [J] . Daniel Mazza Matos, Felipe Magalh?es Furtado, Roberto Passetto Falc?o Hematology, Transfusion and Cell Therapy . 2015,第5期

机译：来自散发性（非家族性）慢性淋巴细胞性白血病家族的个体中的单克隆B细胞淋巴细胞增多会随着时间的流逝而持续，但不会发展为慢性B细胞淋巴细胞增生性疾病
4. Global Sensitivity Analysis for a Model of B-Cell Chronic Lymphocytic Leukemia Disease Trajectories [C] . Symeon Savvopoulos, Ruth Misener, Nicki Panoskaltsis European Symposium on Computer Aided Process Engineering . 2015

机译：B细胞慢性淋巴细胞白血病术术模型的全局敏感性分析
5. The role of P53 in DNA damage response and MLL re-arranged leukemia chemosensitivity [D] . Bae, Narae. 2013

机译：P53在DNA损伤反应和MLL重排白血病化学敏感性中的作用
6. Monoclonal B-cell lymphocytosis in individuals from sporadic (non-familial) chronic lymphocytic leukemia families persists over time but does not progress to chronic B-cell lymphoproliferative diseases [O] . Daniel Mazza Matos, Felipe Magalhães Furtado, Roberto Passetto Falcão 2015

机译：来自散发性（非家族性）慢性淋巴细胞性白血病家族的个体中的单克隆B细胞淋巴细胞增多会随着时间的流逝而持续但不会发展为慢性B细胞淋巴细胞增生性疾病
7. Chronic lymphocytic leukemia–like monoclonal B-cell lymphocytosis exhibits an increased inflammatory signature that is reduced in early-stage chronic lymphocytic leukemia [O] . Gonzalo Blanco, Anna Puiggros, Barbara Sherry, 2021

机译：慢性淋巴细胞白血病样单克隆B细胞淋巴细胞表现出增加炎症特征，其早期慢性淋巴细胞白血病降低

Accumulation of DNA damage and alteration of the DNA damage response in monoclonal B-cell lymphocytosis and chronic lymphocytic leukemia

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