...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Lipids >Sphingolipid metabolism in colorectal adenomas varies depending on histological architecture of polyps and grade of nuclear dysplasia
【24h】

Sphingolipid metabolism in colorectal adenomas varies depending on histological architecture of polyps and grade of nuclear dysplasia

机译：结肠直肠腺瘤中的鞘脂代谢根据息肉和核发育不良等级的组织学架构而变化

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Incidence of colorectal cancer (CRC) is growing worldwide. Pathogenetic mechanisms responsible for its onset and progression need further clarification. Colorectal adenomatous polyps are precancerous lesions with malignant potential dependent on histological architecture and grade of nuclear dysplasia. One of the factors conditioning CRC development are abnormalities in sphingolipid metabolism. The aim of this study was to assess the levels of sphingolipids in human colorectal adenomas. The control group (C, n = 12) consisted of patients with no colonic polyps. The examined group consisted of patients with prior diagnosed colonic polyps, qualified to endoscopic polypectomy. This group was further divided due to histological architecture into tubular adenomas group (TA, n = 10), tubulovillous adenomas with low-grade dysplasia (LGD-TVA, n = 10), and tubulovillous adenomas group with high-grade dysplasia (HGD-TVA, n = 11). In tissue samples, sphingolipd metabolite contents were measured using high performance liquid chromatography (HPLC). In cases of polypoid lesions with low malignancy potential (tubular adenomas), concentration of ceramide, which is characterized by proapoptotic and anti-proliferative properties, increases compared with control group (p < 0.05), whereas content of sphingosine-1-phosphate with anti-apoptotic and stimulating cellular proliferation properties is reduced in comparison with control group (p < 0.05). On the contrary, in cases of more advanced form of adenomatous polyps (tubulovillous adenomas with high-grade dysplasia), the ceramide level decreases compared with control group (p < 0.05) while sphingosine-1-phosphate concentration is elevated (p < 0.05). We found that concentrations of pro-apoptotic ceramide are decreased and pro-proliferative S1P levels are increased in polypoid lesions with high malignancy potential, and it was the opposite in those with low malignancy potential.
机译：结直肠癌（CRC）的发病率在全世界生长。对其发病和进展负责的致病机制需要进一步澄清。结肠直肠腺瘤息肉是具有依赖于组织学建筑和核发育性等级的恶性潜力的癌前病变。调节CRC发育的因素之一是鞘磷脂代谢的异常。本研究的目的是评估人结肠直肠腺瘤中的鞘脂的水平。对照组（C，N = 12）由没有结肠息肉的患者组成。所检查的组由患有现有诊断的结肠息肉的患者组成，符合内窥镜核切除术。由于组织学架构进一步除以管状腺瘤组（TA，N = 10），用低级发育不良（LGD-TVA，N = 10）的小管腺瘤和具有高级别发育不良的小管腺瘤（HGD- TVA，n = 11）。在组织样品中，使用高效液相色谱（HPLC）测量鞘磷脂代谢物含量。在具有低恶性潜力（管状腺瘤）的息肉膜病变的情况下，与对照组相比，氨酰胺的浓度，其特征在于凋亡和抗增殖性质（P <0.05），而乙型磷酸氨基-1-磷酸盐的含量增加 - 与对照组相比，-Apoptoratic和刺激细胞增殖性能（P <0.05）。相反，在更先进的腺瘤息肉形式的情况下（具有高级别发育不良的管状腺瘤），与对照组相比，神经酰胺水平降低（P <0.05），而鞘氨氨酸-1-磷酸浓度升高（P <0.05） 。我们发现促凋亡神经酰胺的浓度降低，并且在具有高恶性潜力的息肉外病变中增加了促增殖性S1P水平，并且恶性潜力低的那些中相反。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号