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首页> 外文期刊>Radiation Research: Official Organ of the Radiation Research Society >Hematological Effects of Non-Homogenous Ionizing Radiation Exposure in a Non-Human Primate Model
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Hematological Effects of Non-Homogenous Ionizing Radiation Exposure in a Non-Human Primate Model

机译：非均匀电离辐射暴露在非人类气密模型中的血液学作用

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Detonation of a radiological or nuclear device in a major urban area will result in heterogenous radiation exposure, given to the significant shielding of the exposed population due to surrounding structures. Development of biodosimetry assays for triage and treatment requires knowledge of the radiation dose-volume effect for the bone marrow (BM). This proof-of-concept study was designed to quantify BM damage in the non-human primate (NHP) after exposure to one of four radiation patterns likely to occur in a radiological/nuclear attack with varying levels of BM sparing. Rhesus macaques (11 males, 12 females; 5.30-8.50 kg) were randomized by weight to one of four arms: 1. bilateral total-body irradiation (TBI); 2. unilateral TBI; 3. bilateral upper half-body irradiation (UHBI); and 4. bilateral lower half-body irradiation (LHBI). The match-point for UHBI vs. LHBI was set at 1 cm above the iliac crest. Animals were exposed to 4 Gy of 6 MV X rays. Peripheral blood samples were drawn 14 days preirradiation and at days 1, 3, 5, 7 and 14 postirradiation. Dosimetric measurements after irradiation indicated that dose to the mid-depth xiphoid was within 6% of the prescribed dose. No high-grade fever, weight loss >10%, dehydration or respiratory distress was observed. Animals in the bilateral and unilateral TBI arms presented with hematologic changes [e.g., absolute neutrophil count (ANC) <500/mu l; platelets <50,000/mu l] and clinical signs/symptoms (e.g., petechiae, ecchymosis) characteristic of the acute radiation syndrome. Animals in the bilateral UHBI arm presented with myelosuppression; however, none of the animals developed severe neutropenia or thrombocytopenia (ANC remained >500/mu l; platelets >50,000/mu l during 14-day follow-up). In contrast, animals in the LHBI arm (1 cm above the ilieac crest to the toes) were protected against BM toxicity with no marked changes in hematological parameters and only minor gross pathology [petechiae (1/5), splenomegaly (1/5) and m
机译：在主要城市地区的放射或核装置的爆炸将导致异源辐射暴露，给出由于周围结构引起的暴露群体的显着屏蔽。用于分类和治疗的生物渗透压测定的发展需要了解骨髓（BM）的辐射剂量效应。这种概念证据旨在在暴露于在放射/核发作中发生的四种辐射模式之一后量化非人灵长类动物（NHP）中的BM损伤，其具有不同水平的BM备件。恒河猴（11名男性，12名女性; 5.30-8.50千克）被四个武器中的一个随机分配：1。双侧全身辐照（TBI）; 2.单方面TBI; 3.双侧上半身辐射（UHBI）; 4.双侧下半身辐照（LHBI）。 UHBI与LHBI的比赛点设定为1厘米以上髂嵴。将动物暴露于4 Gy的6 mV X射线。外周血样品14天的预热，并在第1,3,5,7和14天的后照射。照射后的剂量测量表明中间Xiphoid的剂量在规定剂量的6％以内。没有高档发热，体重减轻> 10％，观察到脱水或呼吸窘迫。患有血液学变化的双侧和单侧TBI臂中的动物[例如，绝对中性粒细胞计数（ANC）<500 / mu;血小板<50,000 / mu l]和临床症状/症状（例如，Petechiae，Ecchymosis）的急性辐射综合征的特征。双侧uhbi手臂的动物患有髓抑制;然而，没有动物产生严重的中性粒细胞减少或血小板减少（ANC保持> 500 / mu L; Platelets> 50,000 / mu L期间的血小板）。相比之下，LHBI臂（1cm以上脚趾上方1厘米）的动物免受BM毒性，没有明显的血液学参数变化，只有轻微的病理学[Petechiae（1/5），脾肿大（1/5）和M.

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    Jackson Isabel L.; Gibbs Allison; Poirier Yannick; Wathen Lynne; Eley John; Draeger Emily; Gopalakrishnan Mathangi; Benjamin Biju; Vujaskovic Zeljko;

  • 作者单位

    Univ Maryland Sch Med Dept Radiat Oncol Div Translat Radiat Sci Baltimore MD 21201 USA;

    Univ Maryland Sch Med Dept Radiat Oncol Div Translat Radiat Sci Baltimore MD 21201 USA;

    Univ Maryland Sch Med Dept Radiat Oncol Div Translat Radiat Sci Baltimore MD 21201 USA;

    Univ Maryland Sch Pharm Ctr Translat Med Baltimore MD 21201 USA;

    Univ Maryland Sch Med Dept Radiat Oncol Div Translat Radiat Sci Baltimore MD 21201 USA;

    Univ Maryland Sch Med Dept Radiat Oncol Div Translat Radiat Sci Baltimore MD 21201 USA;

    US Dept HHS Div Diagnost &

    Med Devices Biomed Adv Res &

    Dev Author Off Assistant Secretary Preparedness &

    Response Washington DC 20024 USA;

    US Dept HHS Div Diagnost &

    Med Devices Biomed Adv Res &

    Dev Author Off Assistant Secretary Preparedness &

    Response Washington DC 20024 USA;

    Univ Maryland Sch Med Dept Radiat Oncol Div Translat Radiat Sci Baltimore MD 21201 USA;

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  • 正文语种 eng
  • 中图分类 辐射与测量;
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