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首页> 外文期刊>Radiation Research: Official Organ of the Radiation Research Society >Translocation Frequency in Patients with Repeated CT Exposure: Comparison with CT-Naive Patients
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Translocation Frequency in Patients with Repeated CT Exposure: Comparison with CT-Naive Patients

机译：重复CT暴露患者的易位频率：与CT天真患者的比较

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摘要

Epidemiologic studies using clinical indicators are limited in the assessment of the biological effects of low-dose ionizing radiation for medical purposes. We evaluated the biological effect of low-dose radiation by comparing translocation frequencies in patients with repeated computed tomography (CT) exposure and CT-naive patients. The goal of this prospective case-control study was to determine whether repeated CT exposure is associated with increased frequency in chromosomal translocations. Two cohorts, comprised of case patients with a history of repeated CT exposure and age- and sex-matched CT-naive control patients (n = 48 per cohort), were consecutively enrolled in this single-institution study. CT-radiation exposure was estimated using dose-length products, and translocation frequencies of peripheral blood lymphocytes were assessed using whole chromosome paints by fluorescence in situ hybridization (FISH). Comparison of translocation frequencies between cases and controls was performed using the Wilcoxon rank sum test (paired samples), and the relationship between cumulative radiation exposure and translocation frequency was assessed using a partial correlation analysis. Translocation frequencies were significantly different between cases and controls (P = 0.003). The median translocation frequency was 7 [95% confidence interval (CI): 6, 8] for cases and 4 (95% CI: 3, 6) for controls. By using cumulative radiation exposure as the effect variable and translocation frequency as the response variable, we found a significant correlation between cumulative radiation exposure and translocation frequency (r = 0.6579, P < 0.0001). Chromosomal translocations were more frequent with repeated CT-exposed patients than in CT-naive patients, and a positive dose-response relationship was present between cumulative radiation exposure and translocation frequency. (C) 2019 by Radiation Research Society
机译：利用临床指标的流行病学研究是有限的，评估低剂量电离辐射的医学目的的生物学效应。我们通过比较重复计算断层扫描（CT）暴露和CT-NAIVAL患者患者的易位频率来评估低剂量辐射的生物学效果。该前瞻性病例对照研究的目标是确定反复的CT暴露是否与染色体易位的频率增加相关。由患有患有反复CT暴露和性别匹配的CT-NAIVED对照患者的病史（每群队的患者和性别匹配的CT-NAIVED对照患者组成的两个群组，在这项单一机构研究中连续纳入。使用剂量长度产品估计CT-辐射暴露，并使用全染色体涂料来评估外周血淋巴细胞的易位频率，通过荧光原位杂交（鱼）。使用Wilcoxon秩和测试（配对样本）执行病例和控制之间的易位频率的比较，并且使用部分相关性分析评估累积辐射曝光和易位频率之间的关系。易位频率在病例和控制之间显着差异（P = 0.003）。对于病例，中值易位频率为7 [95％置信区间（CI）：6,8]，4（95％CI：3,6）进行对照。通过使用累积辐射曝光作为效果变量和易位频率作为响应变量，我们发现累积辐射曝光和易位频率之间的显着相关性（r = 0.6579，p <0.0001）。染色体易位比在CT天真患者中，重复的CT暴露患者更频繁，累积辐射暴露和易位频率之间存在阳性剂量 - 反应关系。 （c）2019由辐射研究协会

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    Lee Jin Kyung; Lee Myoung Seok; Moon Min Hoan; Woo Hyunsik; Hong Young Jun; Jang Seongjae; Oh Sohee;

  • 作者单位

    Korea Inst Radiol &

    Med Sci Korea Canc Ctr Hosp Dept Lab Med Seoul South Korea;

    Seoul Natl Univ SMG SNU Boramae Med Ctr Dept Radiol Coll Med 5 Gil 20 Boramae Rd Seoul 07061 South Korea;

    Seoul Natl Univ SMG SNU Boramae Med Ctr Dept Radiol Coll Med 5 Gil 20 Boramae Rd Seoul 07061 South Korea;

    Seoul Natl Univ SMG SNU Boramae Med Ctr Dept Radiol Coll Med 5 Gil 20 Boramae Rd Seoul 07061 South Korea;

    Korea Inst Radiol &

    Med Sci Korea Canc Ctr Hosp Dept Lab Med Seoul South Korea;

    Korea Inst Radiol &

    Med Sci Korea Canc Ctr Hosp Lab Biol Dosimetty Seoul South Korea;

    Seoul Natl Univ SMG SNU Boramae Med Ctr Dept Biostat Coll Med Seoul South Korea;

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  • 正文语种 eng
  • 中图分类 辐射与测量;
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