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首页> 外文期刊>Radiation Research: Official Organ of the Radiation Research Society >Modeling Cell and Tumor-Metastasis Dosimetry with the Particle and Heavy Ion Transport Code System (PHITS) Software for Targeted Alpha-Particle Radionuclide Therapy.
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Modeling Cell and Tumor-Metastasis Dosimetry with the Particle and Heavy Ion Transport Code System (PHITS) Software for Targeted Alpha-Particle Radionuclide Therapy.

机译：用粒子和重离子传输代码系统（料理）软件对靶向α-粒子放射核素治疗的颗粒和重离子传输码系统（PHITS）软件进行建模细胞和肿瘤转移剂量。

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The use of targeted radionuclide therapy for cancer is on the rise. While beta-particle-emitting radionuclides have been extensively explored for targeted radionuclide therapy, alpha-particle-emitting radionuclides are emerging as effective alternatives. In this context, fundamental understanding of the interactions and dosimetry of these emitted particles with cells in the tumor microenvironment is critical to ascertaining the potential of alpha-particle-emitting radionuclides. One important parameter that can be used to assess these metrics is the S-value. In this study, we characterized several alpha-particle-emitting radionuclides (and their associated radionuclide progeny) regarding S-values in the cellular and tumor-metastasis environments. The Particle and Heavy Ion Transport code System (PHITS) was used to obtain S-values via Monte Carlo simulation for cell and tumor metastasis resulting from interactions with the alpha-particle-emitting radionuclides, lead-212 (~(212)Pb), actinium-225 (~(225)Ac) and bismuth-213 (~(213)Bi); these values were compared to the beta-particle-emitting radionuclides yttrium-90 (~(90)Y) and lutetium-177 (~(177)Lu) and an Auger-electron-emitting radionuclide indium-111 (~(111)In). The effect of cellular internalization on S-value was explored at increasing degree of internalization for each radionuclide. This aspect of S-value determination was further explored in a cell line-specific fashion for six different cancer cell lines based on the cell dimensions obtained by confocal microscopy. S-values from PHITS were in good agreement with MIRDcell S-values (cellular S-values) and the values found by Hindié et al. (tumor S-values). In the cellular model,~(212)Pb and~(213)Bi decay series produced S-values that were 50- to 120-fold higher than~(177)Lu, while~(225)Ac decay series analysis suggested S-values that were 240- to 520-fold higher than~(177)Lu. S-values arising with 100% cellular internalization were two- to sixfold higher for t
机译：使用针对性的放射性核素治疗癌症正在上升。虽然β-颗粒发光的放射性核素已被广泛探索针对靶向放射性核素治疗，但是α-颗粒发光的放射性核素是有效的替代品。在这种情况下，对肿瘤微环境中细胞的这些发射颗粒的相互作用和剂量的基本理解对于确定α-颗粒发射放射核素的电位至关重要。可用于评估这些度量的一个重要参数是S值。在该研究中，我们表征了关于细胞和肿瘤转移环境中的S值的几种α颗粒发光的放射性核素（及其相关的放射性核素后代）。颗粒和重离子传输代码系统（pHITS）用于通过与α-粒子发射放射核素的相互作用相互作用的细胞和肿瘤转移来获得S值，得到α-颗粒发光的放射性核素，LIX-212（〜（212）Pb）， Actinium-225（〜（225）AC）和Biscuth-213（〜（213）BI）;将这些值与β-颗粒发光的放射性核素Yttrium-90（〜（90）Y）和尿液-177（〜（177）Lu）和螺旋钻 - 电子放射性核素铟-111进行比较（〜（111） ）。探讨了每种放射性核素的内部化程度的植物内化对S值的影响。基于通过共聚焦显微镜获得的细胞尺寸，以六种不同癌细胞系的细胞系特异性方式进一步探索S值测定的这一方面。来自界面的S值与MiRdcell S值（蜂窝S值）吻合良好，Hindié等人发现的值。 （肿瘤S值）。在蜂窝模型中，〜（212）PB和〜（213）BI衰减系列产生的S值高于〜（177）Lu，而〜（225）交流衰减序列分析建议S-比〜（177）LU高度为240至520倍的值。具有100％蜂窝内化的S值为t的T.T为2至六倍

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