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首页> 外文期刊>Rapid Communications in Mass Spectrometry: RCM >Rapid detection of explosive vapors by thermal desorption atmospheric pressure photoionization differential mobility analysis tandem mass spectrometry
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Rapid detection of explosive vapors by thermal desorption atmospheric pressure photoionization differential mobility analysis tandem mass spectrometry

机译：通过热解吸型大气压光离子型差动迁移率分析串联质谱法快速检测爆炸性蒸气

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Rationale The increased frequency in the number of international terror threats has led to a corresponding increase in demand for fast, sensitive and reliable screening methods suitable for the detection of airborne explosive vapors. We demonstrate herein a workflow suitable for the determination of nitrogen-based explosives at the picogram level in just minutes. Methods A method is described that combines Thermal Desorption (TD) sample introduction with Differential Mobility Analysis (DMA) Tandem Mass Spectrometry (MS/MS), enabling a sensitive and accurate workflow suitable for the rapid detection of trace nitroaromatic, nitroester and nitramine explosive vapors. The methods are bridged using a novel low-flow, field-free Atmospheric Pressure Photoionization (APPI) source, intended specifically for the analysis of gas-phase analytes and airborne particles. Results Limits of detection within or below the picogram range were determined for the analysis of a range of explosives standards including 2,6-DNT, TNT, TATB, Tetryl, RDX, EGDN, PETN, HMX, and NG. Practical application of the TD-APPI-DMA-MS/MS workflow was demonstrated for the detection of real trace explosive vapors produced from the volatilization of solid explosive samples stored within a sealed cardboard box. A single complete analysis was performed in less than 2 min. Conclusions The highly sensitive and accurate detection of a variety of common nitrogen-based explosive vapors has been demonstrated, at levels suitable for practical, high-throughput security screening applications.
机译：理由，国际恐怖威胁数量的增加的频率导致了对适合检测空气爆炸蒸气的快速，灵敏和可靠的筛选方法的需求相应增加。我们在此证明了适合于在短短几分钟内在皮科水平下测定氮炸药的工作流程。方法描述一种方法，其将热解吸（Td）样品引入与差分迁移率分析（DMA）串联质谱（MS / MS）相结合，实现了适合于痕量硝基芳族，硝基酯和硝基氨基酯蒸气的快速检测的敏感和准确的工作流程。该方法使用新颖的低流量，无现场大气压光离移（APPI）源桥接，专门用于分析气相分析物和空气传播颗粒。结果测定了在微微图范围内或下方的检测限制用于分析一系列炸药标准标准，包括2,6-DNT，TNT，TATB，TETRYL，RDX，EGDN，PETN，HMX和NG。对于TD-APPI-DMA-MS / MS工作流程的实际应用，证明了检测从储存在密封纸板箱内的固体爆炸样品的挥发产生的实际痕量爆炸蒸气。单个完全分析在不到2分钟内进行。结论已经证明了高度敏感和准确的各种常用氮气爆炸蒸气的检测，适用于实用，高通量安全筛查应用的水平。

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