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首页> 外文期刊>Rapid prototyping journal >Influence of selective laser sintering process parameters on microstructure and physicochemical properties of poly(vinyl alcohol) for the production of scaffolds
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Influence of selective laser sintering process parameters on microstructure and physicochemical properties of poly(vinyl alcohol) for the production of scaffolds

机译：选择性激光烧结工艺参数对聚（乙烯醇）微观结构和物理化学性能的影响

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Purpose This study aims to investigate the production of scaffolds by selective laser sintering (SLS) using poly(vinyl alcohol) (PVA) polymer, forin vitrostudies, a relatively new and growing area in which scaffolds could be used in the design of three-dimensional models forin vitrodisease model or tissue equivalent for safety and effectiveness tests. Design/methodology/approach The influence of the SLS process parameters laser power, 26 W and 32 W, and number of laser scans, 1, 2, 4 and 6, on the surface microstructure of the samples and on the degree of crystallinity and chemical stability of PVA material, was investigated using powder with particle size of 20-320 mu m. Laser sintered PVA samples were subjected to cell culture tests using osteoblastic cells derived from human osteosarcoma (SaOs-2). Findings The laser power has no significant influence on the microstructure of the laser-sintered samples, however the number of scans has a considerable influence on the sintering degree; the SLS process causes a decrease in the degree of crystallinity and changes the chemical structure of the as-received PVA, especially when using higher laser power and more number of scans. Preliminaryin vitrocell culture tests show that the laser-sintered PVA material is biocompatible with SaOs-2 cells. Originality/value SLS offers good potential for the fabrication of scaffolds and thus, may be applied as an alternative to conventional scaffold fabrication processes to overcome their limitations.
机译：目的本研究旨在通过使用聚（乙烯醇）（PVA）聚合物，vitrostudies，一种相对较新的和生长区域的选择性激光烧结（SLS）来调查支架的生产支架，其中支架可以在三维设计中使用支架。模型用于玻璃型酶模型或组织等同于安全性和有效性测试。设计/方法/接近SLS工艺参数激光功率，26W和32W的影响，以及激光扫描的数量，1,2,4和6，在样品的表面微观结构和结晶度和化学质量上使用粒度为20-320μm的粉末研究PVA材料的稳定性。使用衍生自人骨瘤瘤（SAOS-2）的骨细胞细胞进行激光烧结PVA样品。发现激光功率对激光烧结样品的微观结构没有显着影响，但扫描的数量对烧结程度相当影响; SLS过程导致结晶度降低，并改变由较高激光功率和更多扫描时的接收PVA的化学结构。预吡喃菊酯培养蛋白培养试验表明，激光烧结的PVA材料与SAOS-2细胞生物相容。原始性/值SLS为支架制造提供良好的潜力，因此，可以作为常规支架制造工艺的替代方法应用以克服它们的限制。

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