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Biotechnological production of aromatic compounds of the extended shikimate pathway from renewable biomass

机译：来自可再生生物质的延长Shikimation途径的生物技术生产

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Aromatic chemicals that contain an unsaturated ring with alternating double and single bonds find numerous applications in a wide range of industries, e.g. paper and dye manufacture, as fuel additives, electrical insulation, resins, pharmaceuticals, agrochemicals, in food, feed and cosmetics. Their chemical production is based on petroleum (BTX; benzene, toluene, and xylene), but they can also be obtained from plants by extraction. Due to petroleum depletion, health compliance, or environmental issues such as global warming, the biotechnological production of aromatics from renewable biomass came more and more into focus. Lignin, a complex polymeric aromatic molecule itself, is a natural source of aromatic compounds. Many microorganisms are able to catabolize a plethora of aromatic compounds and interception of these pathways may lead to the biotechnological production of value-added aromatic compounds which will be discussed for Corynebacterium glutamicum. Biosynthesis of aromatic amino acids not only gives rise to l-tryptophan, L-tyrosine and l-phenylalanine, but also to aromatic intermediates such as dehydroshikimate or chorismate from which value-added aromatic compounds can be derived. In this review, we will summarize recent strategies for the biotechnological production of aromatic and related compounds from renewable biomass by Escherichia coli, Pseudomonas putida, C. glutamicum and Saccharomyces cerevisiae. In particular, we will focus on metabolic engineering of the extended shikimate pathway. (C) 2016 Elsevier B.V. All rights reserved.
机译：含有不饱和环的芳族化学品，交替的双和单键在各种行业中找到了许多应用，例如，纸和染料制造，作为燃料添加剂，电气绝缘，树脂，药品，农用化学品，食品，饲料和化妆品。它们的化学生产基于石油（BTX;苯，甲苯和二甲苯），但它们也可以通过提取从植物中获得。由于石油消耗，健康合规性或全球变暖等环境问题，可再生生物量的芳烃的生物技术生产越来越焦点。木质素是一种复杂的聚合物芳族分子本身，是芳族化合物的天然来源。许多微生物能够分解血清芳族化合物，并且这些途径的截取可能导致增值芳族化合物的生物技术生产，这些化合物将被讨论为棒状杆菌谷氨酰胺。芳族氨基酸的生物合成不仅会产生L-色氨酸，L-酪氨酸和L-苯丙氨酸，还产生芳族中间体，例如脱氢气候或酸酸，从而可以得出增值芳族化合物。在这篇综述中，我们将总结最近通过大肠杆菌，假单胞菌普赖达，C.谷氨酰胺和酿酒酵母的可再生生物量的生物技术生产生物技术生产的战略。特别是，我们将专注于扩展Shikimate途径的代谢工程。 （c）2016年Elsevier B.v.保留所有权利。

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