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首页> 外文期刊>Liver international : >Abnormalities in the 24‐hour rhythm of skin temperature in cirrhosis: Sleep‐wake and general clinical implications
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Abnormalities in the 24‐hour rhythm of skin temperature in cirrhosis: Sleep‐wake and general clinical implications

机译：肝硬化中24小时节奏的24小时节奏的异常：睡眠唤醒和一般临床意义

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Abstract Background & Aims Sleep preparation/onset are associated with peripheral vasodilatation and a decrease in body temperature. The hyperdynamic syndrome exhibited by patients with cirrhosis may impinge on sleep preparation, thus contributing to their difficulties falling asleep. The aim of this study was the assessment of skin temperature, in relation to sleep‐wake patterns, in patients with cirrhosis. Methods Fifty‐three subjects were initially recruited, and 46 completed the study. Of the final 46, 12 were outpatients with cirrhosis, 13 inpatients with cirrhosis, 11 inpatients without cirrhosis and 10 healthy volunteers. All underwent baseline sleep‐wake evaluation and blood sampling for inflammatory markers and morning melatonin levels. Distal/proximal skin temperature and their gradient ( DPG ) were recorded for 24?hours by a wireless device. Over this period subjects kept a sleep‐wake diary. Results Inpatients with cirrhosis slept significantly less well than the other groups. Inpatients and outpatients with cirrhosis had higher proximal temperature and blunted rhythmicity compared to the other groups. Inpatients with/without cirrhosis had higher distal temperature values and blunted rhythmicity compared to the other groups. Inpatients and outpatients with cirrhosis had significantly lower DPG values compared to the other groups, and DPG reached near‐zero values several hours later. Significant correlations were observed between temperature and sleep‐wake variables and inflammatory markers. Conclusions Alterations of distal/proximal skin temperature, their gradient and their time‐course were observed in patients with cirrhosis, which may contribute to their sleep disturbances.
机译：抽象背景＆amp; AIMS睡眠制备/发作与外周血管舒张和体温降低有关。肝硬化患者展出的高动力学综合征可能会影响睡眠准备，从而有助于他们睡眠困难。本研究的目的是评估肝硬化患者的睡眠唤醒模式的皮肤温度。方法最初招募了五十三个科目，46种完成了这项研究。在最后的46,12中，12名是肝硬化的门诊患者，13名住院患者，肝硬化，11位病例没有肝硬化和10名健康志愿者。所有接受炎症标志物和早晨褪黑激素水平的基线睡眠苏醒评价和血液取样。通过无线设备将远端/近端皮肤温度及其梯度（DPG）记录24小时。在这个时期的主题中，受试者保持着睡眠日记。结果肝硬化的住院患者比其他群体的速度显着少得多。与其他组相比，具有肝硬化的住院患者和肝硬化的门诊患者具有更高的近端温度并钝化节律性。具有/不含肝硬化的住院患者具有更高的远端温度值，与其他组相比具有垂直的节律性。与其他组相比，肝硬化的住院患者和门诊患者显着降低了DPG值，并且DPG在几个小时后达到了零零值。在温度和睡眠唤醒变量和炎症标记之间观察到显着的相关性。结论肝硬化患者观察到远端/近端皮肤温度的变化，它们的梯度及其时间过程，这可能有助于他们的睡眠障碍。

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