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首页> 外文期刊>Regulatory Toxicology and Pharmacology: RTP >Toxicological significance of increased serum alkaline phosphatase activity in dog studies of pesticides: Analysis of toxicological data evaluated in Japan
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Toxicological significance of increased serum alkaline phosphatase activity in dog studies of pesticides: Analysis of toxicological data evaluated in Japan

机译：血清碱性磷酸酶活性血清碱性磷酸酶活性的毒理学意义：日本评估毒理学数据分析

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摘要

Increased serum alkaline phosphatase (ALP) activity is an indicator of hepatobiliary damage in humans and experimental animals. Practically, increased ALP accompanied by no other hepatotoxic changes is often encountered in toxicity studies of pesticides in dogs. Here, we analyzed the toxicological significance of increased ALP in response to 206 pesticides evaluated by the Food Safety Commission of Japan as toxicological evaluation reports in their risk assessment process. Our analysis indicated that increased ALP was more frequent in dogs (108/206) than in rats (36/206). In 87 of 108 pesticides, increased ALP was observed with hepatotoxicity in dogs. However, increased ALP had no specific relationship with certain types of hepatotoxicity and was not a sensitive marker of hepatotoxicity. Approximately 50% of 87 pesticides showing hepatotoxicity also induced liver hypertrophy. No hepatotoxic changes were seen with the remaining 21 pesticides, other than increases in liver weight and/or liver hypertrophy. Most of these 21 pesticides were phenobarbital-like liver metabolism enzyme inducers in rodents. These results suggested that increased ALP was not an indicator of hepatotoxicity in dogs if hepatotoxic findings were absent. This analysis provided a new interpretation of the toxicological significance of ALP in dogs and could contribute to toxicological evaluation of pesticides.
机译：增加的血清碱性磷酸酶（ALP）活性是人类和实验动物中肝血液损伤的指标。实际上，伴随着任何其他肝毒性变化的阿尔卑斯症伴随着犬杀虫剂的毒性研究常常遇到。在这里，我们分析了ALP增加的毒理学意义，响应日本食品安全委员会评估的206种农药作为其风险评估过程中的毒理学评估报告。我们的分析表明，在狗（108/206）中比大鼠（36/206）更频繁地频繁。在108个农药中的87名中，用肝脏肝毒性观察到增加的ALP。然而，增加的ALP与某些类型的肝毒性没有具体关系，并且不是肝毒性的敏感标记。大约50％的87个农药显示肝毒性也诱导肝肥大。除肝脏重量和/或肝肥大的增加之外，剩余的21种农药没有看到肝毒性变化。这些21种农药中的大多数是啮齿动物中的苯甲虫样肝脏代谢酶诱导剂。这些结果表明，如果不存在肝毒性发现，增加的ALP不是狗肝毒性的指标。该分析提供了对犬阿尔卑斯毒性的毒理学意义的新解释，并且可以有助于农药的毒理学评估。

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