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Framework for assessing causality of air pollution-related health effects for reviews of the National Ambient Air Quality Standards

机译:评估空气污染相关健康影响因果关系的框架,以审查国家环境空气质量标准

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摘要

To inform regulatory decisions on the risk due to exposure to ambient air pollution, consistent and transparent communication of the scientific evidence is essential. The United States Environmental Protection Agency (U.S. EPA) develops the Integrated Science Assessment (ISA), which contains evaluations of the policy-relevant science on the effects of criteria air pollutants and conveys critical science judgments to inform decisions on the National Ambient Air Quality Standards. This article discusses the approach and causal framework used in the ISAs to evaluate and integrate various lines of scientific evidence and draw conclusions about the causal nature of air pollution-induced health effects. The framework has been applied to diverse pollutants and cancer and noncancer effects. To demonstrate its flexibility, we provide examples of causality judgments on relationships between health effects and pollutant exposures, drawing from recent ISAs for ozone, lead, carbon monoxide, and oxides of nitrogen. U.S. EPA's causal framework has increased transparency by establishing a structured process for evaluating and integrating various lines of evidence and uniform approach for determining causality. The framework brings consistency and specificity to the conclusions in the ISA, and the flexibility of the framework makes it relevant for evaluations of evidence across media and health effects. Published by Elsevier Inc.
机译:为了告知由于暴露于环境空气污染而导致的风险的监管决定,科学证据的一致和透明沟通至关重要。美国环境保护局(美国环保局)开发了综合科学评估(ISA),其中包含对标准空气污染物的影响的政策相关科学的评估,并传达关键科学判断,以告知国家环境空气质量标准的决策。本文讨论了ISAS中使用的方法和因果框架,以评估和整合各种科学证据并得出关于空气污染诱导的健康效应的因果性的结论。该框架已应用于不同的污染物和癌症和非癌症效果。为了展示其灵活性,我们提供了对健康效应和污染物暴露之间的关系的因果关系判断的例子,从近期臭氧,铅,一氧化碳和氮的氧化物中绘制。美国EPA的因果框架通过建立了用于评估和整合各种证据和统一方法来确定因果关系的结构化进程而增加了透明度。该框架为ISA中的结论带来了一致性和特异性,框架的灵活性使其与媒体和健康影响的证据评估相关。 elsevier公司发布

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