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首页> 外文期刊>Radiotherapy and oncology: Journal of the European Society for Therapeutic Radiology and Oncology >In vitro biological response of cancer and normal tissue cells to proton irradiation not affected by an added magnetic field
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In vitro biological response of cancer and normal tissue cells to proton irradiation not affected by an added magnetic field

机译：癌症和正常组织细胞的体外生物反应，以质子辐射不受添加磁场的影响

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摘要

To optimize beam delivery and conformality of proton therapy, MRI integration has been proposed. Therefore, we investigated if proton irradiation in a magnetic field would change biological responses. Our data in cancer cell lines and stem cell-derived organoid models suggest that a magnetic field does not modify the biological response. The primary objective of radiotherapy as a cancer treatment is to eradicate tumor cells while minimizing the effects to surrounding healthy tissues [1]. Due to their physical nature, particles, such as protons, can be used for more conformal dose delivery to the tumor than photon-based conventional irradiation techniques, thus more effectively sparing normal tissue from unnecessary doses [2-5]. Real-time imaging during proton therapy could further optimize the delivery of the beam to patients and offer even more accurate normal tissue sparing [6]. The good soft-tissue contrast of magnetic resonance imaging (MRI) in radiotherapy is very useful. Indeed, MRI has been successfully integrated into photon-based radiotherapy devices [7-9]. However, integration of MRI into proton radiotherapy changes various aspects of dose delivery. It has been shown that the application of a magnetic field to a proton beam can both decrease the depth of the Bragg peak and laterally shift the beam [10]. This shift can be accurately predicted [10] and therefore compensated for. However, although MRI has been successfully integrated into IMRT devices [9], the biological effects of an added magnetic field during proton irradiation have not yet been investigated. Therefore, the aim of this study was to determine if proton irradiation in a magnetic field would induce differential biological outcomes to proton irradiation alone.
机译：为了优化质子疗法的光束输送和适系，提出了MRI集成。因此，我们研究了磁场中的质子辐射会改变生物反应。我们在癌细胞系和干细胞衍生的有机体模型中的数据表明磁场不会改变生物反应。作为癌症治疗的放射治疗的主要目标是消除肿瘤细胞，同时最小化对周围健康组织的影响[1]。由于它们的物理性质，诸如质子的颗粒可以用于比基于光子的常规照射技术更具保形剂量递送，从而更有效地使来自不必要的剂量的正常组织[2-5]。质子疗法期间的实时成像可以进一步优化梁向患者的传送，并提供更准确的正常组织备件[6]。放射疗法中磁共振成像（MRI）的良好软组织对比非常有用。实际上，MRI已成功集成到基于光子的放射治疗装置[7-9]中。然而，将MRI的整合到质子放射疗法改变了剂量递送的各个方面。已经表明，将磁场施加到质子梁可以减小布拉格峰的深度并横向地移位梁[10]。可以精确地预测该偏移[10]并因此得到补偿。然而，尽管MRI已成功集成到IMRT器件[9]中，但尚未研究质子辐射期间添加磁场的生物学效应。因此，本研究的目的是确定磁场中的质子辐射是否会使单独的质子辐射诱导差动生物学结果。

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