The purine scaffold Hsp90 inhibitor PU-H71 sensitizes cancer cells to heavy ion radiation by inhibiting DNA repair by homologous recombination and non-homologous end joining

Lee Younghyun; Li Huizi Keiko; Masaoka Aya; Sunada Shigeaki; Hirakawa Hirokazu; Fujimori Akira; Nickoloff Jac A.; Okayasu Ryuichi

首页> 外文期刊>Radiotherapy and oncology: Journal of the European Society for Therapeutic Radiology and Oncology >The purine scaffold Hsp90 inhibitor PU-H71 sensitizes cancer cells to heavy ion radiation by inhibiting DNA repair by homologous recombination and non-homologous end joining

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The purine scaffold Hsp90 inhibitor PU-H71 sensitizes cancer cells to heavy ion radiation by inhibiting DNA repair by homologous recombination and non-homologous end joining

机译：嘌呤支架HSP90抑制剂PU-H71通过抑制通过同源重组和非同源末端连接来抑制DNA修复来敏感癌细胞对重离子辐射

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Background and purpose: PU-H71 is a purine-scaffold Hsp90 inhibitor developed to overcome limitations of conventional Hsp90 inhibitors. This study was designed to investigate the combined effect of PU-H71 and heavy ion irradiation on human tumor and normal cells.

机译：背景和目的：PU-H71是纯磨碎的HSP90抑制剂，用于克服常规HSP90抑制剂的限制。本研究旨在探讨PU-H71和重离子辐照对人肿瘤和正常细胞的综合影响。

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来源
《Radiotherapy and oncology: Journal of the European Society for Therapeutic Radiology and Oncology》 |2016年第1期|共7页
作者
Lee Younghyun; Li Huizi Keiko; Masaoka Aya; Sunada Shigeaki; Hirakawa Hirokazu; Fujimori Akira; Nickoloff Jac A.; Okayasu Ryuichi;
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作者单位

Natl Inst Radiol Sci Dept Basic Med Sci Radiat Damages Chiba Japan;

Natl Inst Radiol Sci Dept Basic Med Sci Radiat Damages Chiba Japan;

Natl Inst Radiol Sci Dept Basic Med Sci Radiat Damages Chiba Japan;

Natl Inst Radiol Sci Dept Basic Med Sci Radiat Damages Chiba Japan;

Natl Inst Radiol Sci Dept Basic Med Sci Radiat Damages Chiba Japan;

Natl Inst Radiol Sci Dept Basic Med Sci Radiat Damages Chiba Japan;

Colorado State Univ Dept Environm &

Radiol Hlth Sci Ft Collins CO 80523 USA;

Natl Inst Radiol Sci Dept Basic Med Sci Radiat Damages Chiba Japan;

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原文格式 PDF
正文语种 eng
中图分类肿瘤学;
关键词
PU-H71; Hsp90; Heavy ion radiotherapy; Radiosensitization; DNA repair;

机译：PU-H71;HSP90;重离子放射疗法;放射敏化;DNA修复;

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专利

1. The purine scaffold Hsp90 inhibitor PU-H71 sensitizes cancer cells to heavy ion radiation by inhibiting DNA repair by homologous recombination and non-homologous end joining [J] . Lee Younghyun, Li Huizi Keiko, Masaoka Aya, Radiotherapy and oncology: Journal of the European Society for Therapeutic Radiology and Oncology . 2016,第1期

机译：嘌呤支架Hsp90抑制剂PU-H71通过抑制同源重组和非同源末端连接的DNA修复，使癌细胞对重离子辐射敏感。
2. Radiosensitization of human lung cancer cells by the novel purine-scaffold Hsp90 inhibitor, PU-H71 [J] . SegawaT., FujiiY., TanakaA., International journal of molecular medicine . 2014,第3期

机译：新型嘌呤支架Hsp90抑制剂PU-H71对人肺癌细胞的放射增敏作用
3. Radiosensitization of human lung cancer cells by the novel purine-scaffold Hsp90 inhibitor, PU-H71 [J] . SegawaTatsuya, FujiiYoshihiro, TanakaAya, International journal of molecular medicine . 2014,第3期

机译：新型嘌呤支架HSP90抑制剂，PU-H71，人肺癌细胞的放射敏化。PU-H71
4. Role of DNA Homologous Recombination and Non-homologous End-Joining in the Maintenance of Chromosomal Integrity [C] . Masao S. Sasaki, Ejichiro Sonoda, Minoru Takata, International congress of radiation research . 2000

机译：DNA同源重组的作用和非同源终端接合在维持染色体完整性
5. Arp2/3 Directly Interacts with DNA through the p41 Subunit and Is Involved in the Non-Homologous End Joining Repair Pathway [D] . ?Lee, Terri 2020

机译：ARP2 / 3 直接通过 P41 亚基与DNA 相互作用，并在非同源末端连接修复途径参与
6. The purine scaffold Hsp90 inhibitor PU-H71 sensitizes cancer cells to heavy ion radiation by inhibiting DNA repair by homologous recombination and non-homologous end joining [O] . Younghyun Lee, Huizi Li, Aya Masaoka, -1

机译：嘌呤支架Hsp90抑制剂PU-H71通过抑制同源重组和非同源末端连接的DNA修复使癌细胞对重离子辐射敏感。
7. Integrin α6β4 signaling switches DNA repair from homologous recombination to non-homologous end-joining pathway to sensitize breast cancer cells to cisplatin [O] . Min Chen, Brock Marrs, Lei Qi, 2019

机译：整合素α6β4信号传感器切换DNA从同源重组到非同源末端接合途径的DNA修复，以使乳腺癌细胞敏化到顺铂
8. Identify in Breast Cancer Stem Cell-Like Cells the Proteins Involved in Non-Homologous End Joining DNA Repair. [R] . Yin, H. 2007

机译：识别乳腺癌干细胞样细胞中涉及非同源末端连接DNa修复的蛋白质。

The purine scaffold Hsp90 inhibitor PU-H71 sensitizes cancer cells to heavy ion radiation by inhibiting DNA repair by homologous recombination and non-homologous end joining

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