Residual tumour hypoxia in head-and-neck cancer patients undergoing primary radiochemotherapy, final results of a prospective trial on repeat FMISO-PET imaging

Loeck Steffen; Perrin Rosalind; Seidlitz Annekatrin; Bandurska-Luque Anna; Zschaeck Sebastian; Zoephel Klaus; Krause Mechthild; Steinbach Joerg; Kotzerke Joerg; Zips Daniel; Troost Esther G. C.; Baumann Michael

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Residual tumour hypoxia in head-and-neck cancer patients undergoing primary radiochemotherapy, final results of a prospective trial on repeat FMISO-PET imaging

机译：在接受初级放射性化学疗法的头颈癌症患者中残留的肿瘤缺氧，重复FMISO-PET成像的前瞻性试验的最终结果

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Background: Hypoxia is a well recognised parameter of tumour resistance to radiotherapy, a number of anticancer drugs and potentially immunotherapy. In a previously published exploration cohort of 25 head and neck squamous cell carcinoma (HNSCC) patients on [F-18]fluoromisonidazole positron emission tomography (FMISO-PET) we identified residual tumour hypoxia during radiochemotherapy, not before start of treatment, as the driving mechanism of hypoxia-mediated therapy resistance. Several quantitative FMISO-PET parameters were identified as potential prognostic biomarkers. Here we present the results of the prospective validation cohort, and the overall results of the study.

机译：背景：缺氧是肿瘤抗疗法的肿瘤耐药参数，许多抗癌药物和潜在的免疫疗法。在先前公布的25头和颈部鳞状细胞癌（HNSCC）含有[F-18]氟代咪唑正电子发射断层扫描（FMISO-PET）的患者中，我们在放射性化学疗法期间发现了残留的肿瘤缺氧，而不是在治疗开始之前，作为驾驶缺氧介导治疗抗性的机制。鉴定出几种定量的FMISO-PET参数被鉴定为潜在的预后生物标志物。在这里，我们提出了前瞻性验证队列的结果，以及研究的整体结果。

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《Radiotherapy and oncology: Journal of the European Society for Therapeutic Radiology and Oncology》 |2017年第3期|共8页
作者
Loeck Steffen; Perrin Rosalind; Seidlitz Annekatrin; Bandurska-Luque Anna; Zschaeck Sebastian; Zoephel Klaus; Krause Mechthild; Steinbach Joerg; Kotzerke Joerg; Zips Daniel; Troost Esther G. C.; Baumann Michael;
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作者单位

Tech Univ Dresden Helmholtz Zentrum Dresden Rossendorf OncoRay Natl Ctr Radiat Res Oncol Biostat;

Tech Univ Dresden Helmholtz Zentrum Dresden Rossendorf OncoRay Natl Ctr Radiat Res Oncol Biostat;

Tech Univ Dresden Helmholtz Zentrum Dresden Rossendorf OncoRay Natl Ctr Radiat Res Oncol Biostat;

Tech Univ Dresden Helmholtz Zentrum Dresden Rossendorf OncoRay Natl Ctr Radiat Res Oncol Biostat;

Tech Univ Dresden Helmholtz Zentrum Dresden Rossendorf OncoRay Natl Ctr Radiat Res Oncol Biostat;

Tech Univ Dresden Univ Hosp Carl Gustav Carus Dresden Germany;

Tech Univ Dresden Helmholtz Zentrum Dresden Rossendorf OncoRay Natl Ctr Radiat Res Oncol Biostat;

Natl Ctr Tumor Dis Partner Site Dresden Dresden Germany;

Tech Univ Dresden Univ Hosp Carl Gustav Carus Dresden Germany;

Eberhard Karls Univ Tubingen Dept Radiat Oncol Tubingen Germany;

Tech Univ Dresden Helmholtz Zentrum Dresden Rossendorf OncoRay Natl Ctr Radiat Res Oncol Biostat;

Tech Univ Dresden Helmholtz Zentrum Dresden Rossendorf OncoRay Natl Ctr Radiat Res Oncol Biostat;

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原文格式 PDF
正文语种 eng
中图分类肿瘤学;
关键词
FMISO-PET; Advanced stage HNSCC; Radiochemotherapy; Prognostic biomarker; Hypoxia;

机译：FMISO-PET;高级阶段HNSCC;放射化学疗法;预后生物标志物;缺氧;

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专利

1. Residual tumour hypoxia in head-and-neck cancer patients undergoing primary radiochemotherapy, final results of a prospective trial on repeat FMISO-PET imaging [J] . Loeck Steffen, Perrin Rosalind, Seidlitz Annekatrin, Radiotherapy and oncology: Journal of the European Society for Therapeutic Radiology and Oncology . 2017,第3期

机译：在接受初级放射性化学疗法的头颈癌症患者中残留的肿瘤缺氧，重复FMISO-PET成像的前瞻性试验的最终结果
2. Correlative analyses between tissue-based hypoxia biomarkers and hypoxia PET imaging in head and neck cancer patients during radiochemotherapy-results from a prospective trial [J] . Nicolay Nils H., Wiedenmann Nicole, Mix Michael, European Journal of Nuclear Medicine and Molecular Imaging . 2020,第5期

机译：在未来试验期间，在放射性化学疗法期间组织缺氧生物标志物与缺氧宠物成像的相关分析 - 从前瞻性试验结果
3. Correlative Analyses between Tissue-Based Hypoxia Biomarkers and Hypoxia PET Imaging in Head and Neck Cancer Patients during Radiochemotherapy: Results from a Prospective Trial [J] . Nicolay N. H., Wiedenmann N., Mix M., International Journal of Radiation Oncology, Biology, Physics . 2019,第1Suppla期

机译：放射性化学治疗中组织缺氧生物标志物和缺氧宠物成像的相关分析：前瞻性试验的结果
4. Multi-atlas-based Segmentation of the Parotid Glands of MR Images in Patients Following Head-and-neck Cancer Radiotherapy [C] . Guanghui Cheng, Xiaofeng Yang, Ning Wu, Conference on computer-aided diagnosis . 2013

机译：头颈癌放疗后患者MR图像腮腺的多图谱分割
5. Telomerase expression as a marker for minimal residual disease detection in patients undergoing second-look laparotomy for ovarian cancer: A follow-up study. [D] . Hughes, Lindsey. 2007

机译：端粒酶表达作为卵巢癌二期剖腹手术患者最小残留疾病检测的标志物：一项后续研究。
6. Repeatability of hypoxia PET imaging using 18FHX4 in lung and head and neck cancer patients: a prospective multicenter trial [O] . Catharina M. L. Zegers, Wouter van Elmpt, Katrin Szardenings, -1

机译：18F HX4在肺和头颈癌患者中使用低氧PET成像的可重复性：一项前瞻性多中心试验
7. Exploratory prospective trial of hypoxia-specific PET imaging during radiochemotherapy in patients with locally advanced head-and-neck cancer [O] . Zips Daniel, Zöphel Klaus, Abolmaali Nasreddin, 2012

机译：局部晚期头颈癌患者放化疗期间低氧特异性PET显像的探索性前瞻性试验

Residual tumour hypoxia in head-and-neck cancer patients undergoing primary radiochemotherapy, final results of a prospective trial on repeat FMISO-PET imaging

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