Radiotherapy dose–volume parameters predict videofluoroscopy-detected dysphagia per DIGEST after IMRT for oropharyngeal cancer: Results of a prospective registry

Mona Kamal; Abdallah S.R. Mohamed; Stefania Volpe; Jhankruti Zaveri; Martha Portwood Barrow; G. Brandon Gunn; Stephen Y. Lai; Renata Ferrarotto; Jan S. Lewin; David I. Rosenthal; Amit Jethanandani; Mohamed Ahmed Mohamed Meheissen; Samuel L. Mulder; Carlos E. Cardenas; Clifton D. Fuller; Katherine A. Hutcheson; MD Anderson Head Neck Cancer Symptom Working Group

首页> 外文期刊>Radiotherapy and oncology: Journal of the European Society for Therapeutic Radiology and Oncology >Radiotherapy dose–volume parameters predict videofluoroscopy-detected dysphagia per DIGEST after IMRT for oropharyngeal cancer: Results of a prospective registry

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Radiotherapy dose–volume parameters predict videofluoroscopy-detected dysphagia per DIGEST after IMRT for oropharyngeal cancer: Results of a prospective registry

机译：放射疗法剂量参数预测IMRT对口咽癌症的吞噬检测的吞咽困困：未来登记处的结果

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PurposeOur primary aim was to prospectively validate retrospective dose–response models of chronic radiation-associated dysphagia (RAD) after intensity modulated radiotherapy (IMRT) for oropharyngeal cancer (OPC). The secondary aim was to validate a grade ≥2 cut-point of the published videofluoroscopic dysphagia severity (Dynamic Imaging Grade for Swallowing Toxicity, DIGEST) as radiation dose-dependent. Material and methodsNinety-seven patients enrolled on an IRB-approved prospective registry protocol with stage I–IV OPC underwent pre- and 3–6?month post-RT videofluoroscopy. Dose–volume histograms (DVH) for swallowing regions of interest (ROI) were calculated. Dysphagia severity was graded per DIGEST criteria (dichotomized with grade ≥2 as moderate/severe RAD). Recursive partitioning analysis (RPA) and Bayesian Information Criteria (BIC) were used to identify dose–volume effects associated with moderate/severe RAD. Results31% developed moderate/severe RAD (i.e. DIGEST grade ≥2) at 3–6?months after RT. RPA found DVH-derived dosimetric parameters of geniohyoid/mylohyoid (GHM), superior pharyngeal constrictor (SPC), and supraglottic region were associated with DIGEST grade ≥2 RAD. V61?≥?18.57% of GHM demonstrated optimal model performance for prediction of DIGEST grade ≥2. ConclusionThe findings from this prospective longitudinal registry validate prior observations that dose to submental musculature predicts for increased burden of dysphagia after oropharyngeal IMRT. Findings also support dichotomization of DIGEST grade ≥2 as a dose-dependent split for use as an endpoint in trials or predictive dose–response analysis of videofluoroscopy results.

机译：目的主要目的是在强度调节放疗（IMRT）后垂直验证慢性辐射相关吞咽（Rad）的回顾剂量 - 响应模型（IMRT），用于口咽癌症（OPC）。二次目的是验证公布的视频荧光吞咽困难性严重程度的≥2分点（动态成像等级，用于吞咽毒性，消化）作为辐射剂量依赖性。材料和方法向IS-IV OPC阶段批准的IRB批准的前瞻性注册协议参加了IRB批准的前瞻性注册课程，进行了第3-6阶段，3-6个？月后的RT videof荧光检查。计算用于吞咽兴趣区域（ROI）的剂量直方图（DVH）。吞咽困难的严重程度是每种摘要标准进行分级（二分法，≥2级为适度/严重Rad）。递归分配分析（RPA）和贝叶斯信息标准（BIC）用于鉴定与中等/严重RAD相关的剂量体积效应。结果311％在3-6次在3-6℃下发育中等/严重的rad（即消化级别≥2）。 RPA发现了基因力醇/蛋白质（GHM），高咽部约束（SPC）的DVH衍生的剂量测定参数，以及超级阶段地区与消化级≥2rad相关。 V61？≥？18.57％的GHM显示了预测消化级别≥2的最佳模型性能。结论从该前瞻性纵向注册表中的发现验证了次源肌肉组织的前景，以预测口咽ICRT后吞咽困难增加的增加。结果还支持消化级别≥2的二分化，作为剂量依赖性分裂，用作荧光综述结果的试验或预测剂量 - 反应分析中的终点。

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《Radiotherapy and oncology: Journal of the European Society for Therapeutic Radiology and Oncology》 |2018年第3期|共10页
作者
Mona Kamal; Abdallah S.R. Mohamed; Stefania Volpe; Jhankruti Zaveri; Martha Portwood Barrow; G. Brandon Gunn; Stephen Y. Lai; Renata Ferrarotto; Jan S. Lewin; David I. Rosenthal; Amit Jethanandani; Mohamed Ahmed Mohamed Meheissen; Samuel L. Mulder; Carlos E. Cardenas; Clifton D. Fuller; Katherine A. Hutcheson; MD Anderson Head Neck Cancer Symptom Working Group;
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作者单位

Department of Radiation Oncology The University of Texas MD Anderson Cancer Center;

Department of Radiation Oncology The University of Texas MD Anderson Cancer Center;

Department of Radiation Oncology The University of Texas MD Anderson Cancer Center;

Department of Head and Neck Surgery The University of Texas MD Anderson Cancer Center;

Department of Head and Neck Surgery The University of Texas MD Anderson Cancer Center;

Department of Radiation Oncology The University of Texas MD Anderson Cancer Center;

Department of Radiation Oncology The University of Texas MD Anderson Cancer Center;

Department of Thoracic/Head and Neck Medical OncologyThe University of Texas MD Anderson Cancer;

Department of Head and Neck Surgery The University of Texas MD Anderson Cancer Center;

Department of Radiation Oncology The University of Texas MD Anderson Cancer Center;

Department of Radiation Oncology The University of Texas MD Anderson Cancer Center;

Department of Radiation Oncology The University of Texas MD Anderson Cancer Center;

Department of Radiation Oncology The University of Texas MD Anderson Cancer Center;

Department of Radiation Physics The University of Texas MD Anderson Cancer Center;

Department of Radiation Oncology The University of Texas MD Anderson Cancer Center;

Department of Head and Neck Surgery The University of Texas MD Anderson Cancer Center;

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原文格式 PDF
正文语种 eng
中图分类肿瘤学;
关键词
Radiotherapy; Dose–volume; Dysphagia; Intensity-modulated radiation therapy; Oropharyngeal cancer; DIGEST;

机译：放疗;剂量体积;吞咽困难;强度调制的放射治疗;口咽癌;消化;

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1. Radiotherapy dose–volume parameters predict videofluoroscopy-detected dysphagia per DIGEST after IMRT for oropharyngeal cancer: Results of a prospective registry [J] . Mona Kamal, Abdallah S.R. Mohamed, Stefania Volpe, Radiotherapy and oncology: Journal of the European Society for Therapeutic Radiology and Oncology . 2018,第3期

机译：放射疗法剂量参数预测IMRT对口咽癌症的吞噬检测的吞咽困困：未来登记处的结果
2. Weekly dose-volume parameters of mucosa and constrictor muscles predict the use of percutaneous endoscopic gastrostomy during exclusive intensity-modulated radiotherapy for oropharyngeal cancer. [J] . Sanguineti G, Gunn GB, Parker BC, International Journal of Radiation Oncology, Biology, Physics . 2011,第1期

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3. A prospective longitudinal assessment of MRI signal intensity kinetics of non-target muscles in patients with advanced stage oropharyngeal cancer in relationship to radiotherapy dose and post-treatment radiation-associated dysphagia: Preliminary findings from a randomized trial [J] . Meheissen Mohamed A. M., Mohamed Abdallah S. R., Kama Mona, Radiotherapy and oncology: Journal of the European Society for Therapeutic Radiology and Oncology . 2019,第期

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4. Role of an imaging informatics-based DICOM-RT cancer registry in evaluating treatment parameters of IMRT for prostate cancer [C] . Ruchi Deshpande, Alyssa Zhou, Jeffrey Zhang, Conference on advanced PACS-based imaging informatics and therapeutic applications . 2013

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5. Analysis of Single Nucleotide Polymorphisms (SNPs) and Dose-volume Parameters on Predicting for Rectal Toxicity, Erectile Dysfunction, and Urinary Morbidity Following Treatment for Prostate Cancer Using Radiotherapy. [D] . Taneja, Sameer. 2014

机译：分析单核苷酸多态性（SNP）和剂量参数对使用放射疗法治疗前列腺癌后的直肠毒性，勃起功能障碍和尿毒症的预测。
6. Radiotherapy dose-volume parameters predict videofluoroscopy-detected dysphagia per DIGEST after IMRT for oropharyngeal cancer: results of a prospective registry [O] . Mona Kamal, Abdallah S. R. Mohamed, Stefania Volpe, -1

机译：放疗剂量体积参数预测IMRT后口咽癌的DIGEST影像学检查发现吞咽困难：前瞻性注册结果
7. Radiation Therapy Dose-Volume Correlates Predict Videofluoroscopy-Detected Dysphagia Per DIGEST after IMRT for Oropharyngeal Carcinoma: Results of a Prospective Registry [O] . M. Kamal, A.S. Mohamed, S. Volpe, 2018

机译：放射治疗剂量体积相关性地相关预测每种消化后的导血荧光吞咽症，以后IMRT为口咽癌癌：预期登记处的结果

Radiotherapy dose–volume parameters predict videofluoroscopy-detected dysphagia per DIGEST after IMRT for oropharyngeal cancer: Results of a prospective registry

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