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首页> 外文期刊>Radiotherapy and oncology: Journal of the European Society for Therapeutic Radiology and Oncology >An evaluation of the mid-ventilation method for the planning of stereotactic lung plans
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An evaluation of the mid-ventilation method for the planning of stereotactic lung plans

机译：立体定向肺计划规划中通风方法的评价

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Background and purpose: Stereotactic ablative body radiotherapy for lung plans requires 4DCT. Most radiotherapy centres use this to determine an internal target volume (ITV), despite studies suggesting that planning on a mid-ventilation (Mid-V) phase can reduce target volumes. The purpose of this study is two-fold: to determine whether the Mid-V approach provides adequate coverage and to discuss methods to enable the Mid-V approach to be applied more widely. Method: 4D scans of 79 patients were outlined on every phase. The mid-V phase was identified. Margins were determined from the range of motion, and plans generated with a 55 Gy prescription. A grid-based method was used to get the probability of tumour coverage in the presence of systematic and random uncertainties, with and without blurring for breathing motion. Results: For the Mid-V plans with the margins calculated from the van-Herk formula, after blurring doses for breathing, the coverage (dose covering 95% of the CTV 95% of the time) was greater than for plans with isotropic 5 mm margins uncorrected for breathing (58.2 Gy v 57.3 Gy). Similar results were obtained for a linear margin chosen as 0.15 of the breathing range. Deformable contour propagation in a commercial outlining system (ProSoma) identified the same mid-V phase in the majority of cases. Conclusion: Our results confirm that a mid-V approach can be used to reduce the PTV size, with no loss of tumour coverage. We propose the use of a simplified margin formula equal to the margin ignoring breathing plus 0.15 of the range of motion.
机译：背景和目的：肺部计划的立体定向烧蚀身体放射治疗需要4DCT。尽管研究表明在中间通风（v）阶段的规划可以减少目标体积，但大多数放射疗法中心使用它可以确定内部目标体积（ITV）本研究的目的是两倍：确定中期方法是否提供了足够的覆盖范围，并讨论了更广泛应用中期方法的方法。方法：每阶段都概述了79名患者的4D扫描。鉴定了中生阶段。利润率是从运动范围内确定的，并用55倍的处方产生的计划。基于网格的方法用于在系统和随机的不确定性存在下获得肿瘤覆盖率的概率，具有和不模糊的呼吸运动。结果：对于中MMGINS的MID-V计划，在模糊剂量呼吸后，覆盖（覆盖95％的CTV 95％的时间）大于各向同性5mm的计划呼吸未经校正的边缘（58.2 GY V 57.3 GY）。为呼吸范围0.15选择的线性边缘获得了类似的结果。商业概述系统（Prosoma）中可变形的轮廓繁殖在大多数情况下鉴定了相同的中V相。结论：我们的结果证实，V中期方法可用于降低PTV尺寸，没有丢失肿瘤覆盖率。我们建议使用简化的边缘公式等于忽略呼吸的边缘加上0.15的运动范围。

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