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首页> 外文期刊>Reviews in analytical chemistry >Design of experiments in liquid chromatography (HPLC) analysis of pharmaceuticals: analytics, applications, implications and future prospects
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Design of experiments in liquid chromatography (HPLC) analysis of pharmaceuticals: analytics, applications, implications and future prospects

机译：液相色谱（HPLC）实验设计药品分析：分析，应用，含义和未来前景

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摘要

This review presents the essential brief annals, crucial analytics, precise applications and noteworthy implications of design of experiments which enrouted to liquid chromatography (LC) in the midst of utmost focus on high-performance liquid-chromatography (HPLC) and broadened its impressions on allied techniques in pharmaceutical analysis. Being most widely applied statistical methodologies for such purpose, its use was started in 1970 and heightened after Fischer's precious input in 1981. The persistent use of statistical approaches one after another led to the efficient attention of pharmaceutical analysts. Hence, in order to fine-tune the trail impressed by the cumulative trends, the use of statistical designs in HPLC analysis has been reviewed and efforts were made to recognize its relative impact and corresponding future prospects. Applications of precise methodologies have been reassessed with respect to the need established by recent regulatory perspectives with a fanatical and the consequent stance on prominent historical advancements and concrete purposes. An effort was also made to state an arbitrary classification of diverse design types and succinct line of application in LC and associated analyses.
机译：本综述提出了基本简短的年份，关键分析，精确的应用，并对实验设计的重要意义，在最大限度地关注高性能液相色谱（HPLC）中，对液相色谱（LC）的设计进行了设计，并扩大了其对盟友的印象药物分析技术。为此目的是最广泛应用的统计方法，其使用于1970年开始，在Fischer在1981年的珍贵投入后提高了。持续使用统计方法之一后，又一次导致药物分析师的有效关注。因此，为了微调累积趋势印象深刻的痕迹，已经过审查了HPLC分析中的统计设计，并努力承认其相对影响和相应的未来前景。关于最近监管观点的需要，已经重新评估了精确的方法，并在狂热的历史进步和具体目的上具有狂热和随后的立场。还努力说明在LC和相关分析中的不同设计类型和简洁的应用程序的任意分类。

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