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首页> 外文期刊>Retina >CHOROIDAL THICKNESS AND VASCULARITY VARY WITH DISEASE SEVERITY AND SUBRETINAL DRUSENOID DEPOSIT PRESENCE IN NONADVANCED AGE-RELATED MACULAR DEGENERATION
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CHOROIDAL THICKNESS AND VASCULARITY VARY WITH DISEASE SEVERITY AND SUBRETINAL DRUSENOID DEPOSIT PRESENCE IN NONADVANCED AGE-RELATED MACULAR DEGENERATION

机译：脉络膜厚度和血管间变化，疾病严重程度和亚阈值衰弱沉积在非冒名年龄相关性黄斑变性中存在

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Purpose: To investigate how choroidal features vary with age-related macular degeneration (AMD) severity in early-intermediate disease. Methods: One hundred fifty-one eyes of 151 participants >50 years with no to intermediate AMD were analyzed with enhanced depth imaging optical coherence tomography. Mean macular choroidal thickness (CT), choroidal vascular thickness (CV), and choroidal vascularity index (CVI) were determined, and statistical associations were calculated. Results: Decreased CT and CV were associated with increased axial length (+30 and +14 mu m/mm, respectively; P < 0.0001 each), whereas decreased CVI was associated with increased age (+0.1%/year; P = 0.004). Compared with eyes with no/early AMD (Group 0), eyes with large drusen without late AMD in the fellow eye (Group 1) showed increased CV and CVI (+22 mu m, P = 0.03 and +2.2%, P = 0.02, respectively). However, eyes with large drusen and late AMD in the fellow eye (Group 2) resembled Group 0. Eyes with subretinal drusenoid deposits demonstrated lower mean CT/CV/CVI than Group 0 (-57 mu m, P = 0.02; -31 mu m, P = 0.02; -3.6%, P = 0.007). Conclusion: Early AMD progression seems associated with biphasic alterations in choroidal dimensions, increasing during early drusen formation but decreasing thereafter. Subretinal drusenoid deposits are independently associated with marked reductions in all choroidal parameters. Changes in choroidal vascular anatomy may drive or reflect the pathobiology of AMD progression.
机译：目的：研究脉络膜功能如何随着早期中间疾病的年龄相关的黄斑变性（AMD）严重程度而变化。方法：用增强深度成像光学相干断层扫描分析151名参与者的151名参与者> 50年，没有中间AMD。确定平均黄斑脉络膜厚度（CT），测定脉络膜血管厚度（CV）和脉络膜血管性指数（CVI），并计算统计学缔合。结果：降低CT和CV与增加的轴向长度（+30和+14μm/ mm）相关;每次P <0.0001），而CVI降低与年龄增加（+ 0.1％/年; P = 0.004） 。与NO /早期AMD（0）的眼睛相比，在眼睛眼睛（第1组）中没有晚期AMD的大型玻璃体的眼睛（第1组）显示出Cv和CVI（+22μm，p = 0.03和+ 2.2％，p = 0.02 ， 分别）。然而，眼睛的眼睛和眼睛中的晚期的眼睛（第2组）类似于群体0.副滴虫沉积物的眼睛表现出低于0（-57μm，p = 0.02;-31μm;-31μm;-31μm;-31μg m，p = 0.02; -3.6％，p = 0.007）。结论：早期的AMD进展似乎与脉络膜尺寸的双相变化有关，早期玻璃葡萄形成过程中的增加，但此后减少。 Subretinal Drusenoid沉积物独立地与所有脉络膜参数的标记减少相关。脉络膜血管解剖结构的变化可能会驾驶或反映AMD进展的病理学。

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