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首页> 外文期刊>Retinal cases & brief reports >DEXAMETHASONE INTRAVITREAL IMPLANT FOR CHOROIDAL NEOVASCULARIZATION DURING PREGNANCY
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DEXAMETHASONE INTRAVITREAL IMPLANT FOR CHOROIDAL NEOVASCULARIZATION DURING PREGNANCY

机译：妊娠期间，地塞米松intraviteal植入脉络膜新生血管

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摘要

Purpose: To describe the management of active choroidal neovascularization (CNV) during pregnancy with the use of a dexamethasone intravitreal implant (DXI) (Ozurdex). Methods: Case series of active CNV treated with DXI with at least 12-month follow-up retrospectively analyzed at 2 high-volume referral centers in France. Medical records and multimodal macular imaging were evaluated. Results: Three eyes of 3 patients (age 30.0 ± 3.6 years) were included. One case of idiopathic CNV and two cases of CNV secondary to multifocal choroiditis were analyzed. Mean follow-up was 20.6 ± 4.0 months (range, 16-23 months). The DXI was given at second trimester of established pregnancy in all cases. Mean central retinal thickness decreased from 359 ± 53 mm to 301 ±17 mm 1 month after DXI and remained stable up to 12 months of follow-up. Visual improvement in all cases was observed (mean 10 letters; range, 5-30 letters) 1 month after DXI and remained stable/increased up to 12-month follow-up (mean 22 letters; range, 10-30 letters). All patients had an uneventful prenatal course and delivered a healthy full-term infant. Conclusion: In the authors' experience, a single DXI revealed safe and effective in CNV treatment during pregnancy.
机译：目的：在妊娠期间描述在妊娠期间的主动脉络膜新生血管化（CNV）的管理，使用地塞米松玻璃体植入物（DXI）（Ozurdex）。方法：用DXI治疗的病例系列活性CNV，在法国的2个大批量推荐中心回顾性分析了至少12个月的随访。评估病历和多模式黄斑成像。结果：包括3名患者的三只眼（30.0岁±3.6岁）。分析了一种特发性CNV和两种CNV次级的次焦脉络炎的情况。平均随访时间为20.6±4.0个月（范围，16-23个月）。 DXI在所有病例中均为已于妊娠的第二个三个月给予。平均中央视网膜厚度从DXI后1个月从359±53毫米降低到301±17毫米，并保持稳定，长达12个月的随访。观察到所有情况的视觉改善（平均10个字母;范围，5-30个字母）1个月后1个月，仍然稳定/增加最多12个月的随访（平均22个字母;范围，10-30个字母）。所有患者都有一个平坦的产前课程，并提供了一个健康的全职婴儿。结论：在作者的经验中，单一DXI在怀孕期间揭示了CNV治疗的安全有效。

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