• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Respiratory physiology & neurobiology >Heating-induced contraction in airways smooth muscle: A possible causative factor of exercise-induced bronchoconstriction
【24h】

Heating-induced contraction in airways smooth muscle: A possible causative factor of exercise-induced bronchoconstriction

机译：加热诱导的气道中的收缩平滑肌：运动诱导的支气管混合物的可能致病因子

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Asthmatic patients often suffer from bronchoconstriction or asthma following breathing hot air or exposure to exercise due to raises the core body temperature. However, the direct effect of heating airways has not been studied yet. The aim of this study is to investigate the effect of heating on tracheal and bronchiolar smooth muscles. Isolated ovine tracheal strips and bronchiolar segments preparations were suspended in organ baths containing Krebs’ solution for isometric tension recording. Tissues responses were examined during decreasing and elevating baths temperature (20?°C, 40?°C–45?°C and 50?°C). Cooling or heating induced rapid and reproducible contractions proportional with decreasing or increasing temperature respectively in tracheal and bronchiolar preparations. On reset to 37?°C the tone returned rapidly to basal level. Changing the bath’s temperature from 37?°C to 20?°C or to 40?°C and 45?°C for tracheal strips or to 45?°C and 50?°C for bronchiolar segments induced contractions in both preparations. Changing the temperature below or above the normal body temperature (37?°C), leads to airways contractions. Heating induced contractions in tracheal and bronchiolar smooth muscle proportional to the heating temperature. Therefore, breathing hot air or elevation of body core temperature due to exercise can be considered possible causative factor of heating- or exercise-induced bronchoconstriction.
机译：哮喘患者常常在呼吸热空气或暴露于磨损芯体温度后患有支气管混合物或哮喘。然而，尚未研究加热气道的直接效果。本研究的目的是探讨加热对气管和支气管平滑肌的影响。分离的绵羊气管条和支气管段制剂悬浮在含有克雷布斯的器官浴中，用于等距张力记录。在减少和升高浴温期间检查组织响应（20℃，40℃，40℃-45°C和50Ω·℃）。冷却或加热诱导与分别在气管和支气管制剂中的减少或增加温度的快速和可再现的收缩。在重置为37°C时，音调迅速返回基础水平。将浴槽的温度从37？℃改变为20？°C或40？℃，45°C，用于气管条或45°C和50Ω℃，用于支气管段在两种制剂中引起收缩。将低于正常体温（37Ω·℃）的温度改变，导致气道收缩。加热引起的气管和支气管轴平滑肌肉与加热温度成比例。因此，由于锻炼引起的呼吸热空气或身体核心温度的高度可以被认为是加热或运动诱导的支气管内的可能性造成因子。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号