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首页> 外文期刊>Reviews in medical microbiology >In-vitro comparison of tigecycline as an alternative to the classical therapy in brucellosis treatment
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In-vitro comparison of tigecycline as an alternative to the classical therapy in brucellosis treatment

机译：将替替硒的体外比较作为布鲁氏菌病治疗典型治疗的替代品

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Brucellosis is an important zoonosis because of its difficult and prolonged treatment regimen; at the same time, it sometimes involves serious complications. The aim of the study was to determine the antibiotic susceptibility profiles of ciprofloxacin, clarithro-mycin, doxycycline, rifampicin, streptomycin, and tigecycline using the E-test method on brucellosis, and the distribution of Brucella species. Forty-four patients (24 men, 20 women) who were admitted to our laboratory between 2014 and 2016 and for whom Brucella bacteria were found to be grown in their blood cultures were included in the study. Blood samples from patients were incubated on BD Bactec Fx. Positive signaling samples were plated on sheep blood agar and eosin methylene blue agar media. The bacteria were then allowed to grow for 48 h in an incubator at 37°C. Gram-negative cocobacillus as a result of Gram staining was identified with the Vitek 2 Compact instrument and the gram negative identification kit. Antibiotic susceptibility tests against ciprofloxacin, clarithromycin, doxycycline, rifampicin, streptomycin, and tigecycline were also evaluated. Twenty four (54.5%) of 44 patients were men, 20 (45.5%) were women and the mean age was 42.5. The youngest patient was 14 and the oldest patient was 86 years old. All of the isolated bacteria (100%) were detected as Brucella melitensis with the fully automated culture antibiogram device (Vitek 2 Compact, Biomerieux). In the evaluation realized by E-test method, the minimum and maximum minimum inhibitory concentration values for each antibiotic taken for study were obtained as follows: for ciprofloxacin, 0.125-0.50 mug/ml; for clarithromycin, 0.32-1 mug/ml; for doxycycline, 0.032-0.64 mug/ml; for rifampicin, 0.016-0.32 mug/ml; for streptomycin, 0.10-0.25 mug/ml; and for tigecycline, 0.125-0.38 mug/ml. B. melitensis was detected as the causative factor in the majority of cases of brucellosis in the world. Furthermore, according to the E-test method, lower minimum inhibitory concentration values for doxycycline, rifampicin, streptomycin, and tigecycline indicate that they are important antimicrobials in the treatment.
机译：由于其困难和长期的治疗方案，布鲁克病是一种重要的动物病;与此同时，它有时涉及严重的并发症。该研究的目的是测定Ciphofloxacin，Clarithro-霉霉素，强霉素，利福平，使用Brucelloss的e-Test方法的抗生素敏感性谱，利福平，链霉素和替霉素，以及Brucella物种的分布。在2014年和2016年间，在2014年至2016年期间录取了我们实验室的四十四名患者（24名男子，20名妇女）在研究中纳入其血液培养中的生长。来自患者的血液样品在BD Bactec FX上培养。在羊血糖和曙红亚甲基蓝琼脂培养基上铺设正信号样品。然后使细菌在37℃下在培养箱中生长48小时。用Vitek 2紧凑型仪器和革兰氏阴性鉴定试剂盒鉴定了由于革氏染色而导致的革兰氏阴性钴霉菌。还评估了对环丙沙星，克拉霉素，十二胞环素，利福平，链霉素和脱癸锌素的抗生素易感性试验。二十四（54.5％）44例患者是男性，20名（45.5％）是女性，平均年龄为42.5。最年轻的患者是14岁，最古老的患者86岁。所有孤立的细菌（100％）被检测为Brucella melitensis，用全自动培养抗体抗体诊断装置（Vitek 2 Compact，BioMerieux）。在通过电子试验方法实现的评价中，如下获得用于研究所采取的每种抗生素的最小和最大最小抑制浓度值：对于环丙沙星，0.125-0.50麦克风/ ml;对于克拉霉素，0.32-1杯/ ml;对于十氧环素，0.032-0.64杯/ ml;对于利福平，0.016-0.32杯/ ml;对于链霉素，0.10-0.25麦克风/ ml;对于Tigecycline，0.125-0.38杯/ ml。 B. Melitensis被发现是世界上大多数Brucellosis病例的致病因素。此外，根据E-Tes​​t方法，较低的十二环菌素，利福平，链霉素和替霉素的最小抑制浓度值表明它们是治疗中的重要抗微生物。

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