...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Resuscitation. >Defibrillation energy dose during pediatric cardiac arrest: Systematic review of human and animal model studies
【24h】

Defibrillation energy dose during pediatric cardiac arrest: Systematic review of human and animal model studies

机译：儿科心脏骤停中的除颤能量剂量：人与动物模型研究的系统审查

获取原文
获取原文并翻译 | 示例
   

获取外文期刊封面封底 >>

       
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Objective: To determine the initial defibrillation energy dose that is associated with sustained return of spontaneous circulation (ROSC) during paediatric cardiac arrest with ventricular fibrillation or pulseless ventricular tachycardia. Methods: A systematic review was performed using four databases (PROSPERO: CRD42016036734). Human studies and animal model studies of pediatric cardiac arrest involving assessment of external defibrillation energy dosing were considered. The primary outcome was sustained ROSC. Survival and defibrillation-induced complications were also evaluated. Results: The search strategy identified 14,471 citations of which 232 manuscripts were reviewed. Ten human and 10 animal model studies met the inclusion criteria. Human studies were prospective (n = 6) or retrospective (n = 4) cohort studies and included between 11 and 266 patients (median = 46 patients). Sustained ROSC rates ranged from 0 to 61 % (n = 7). No studies reported a statistically significant association between the initial defibrillation energy dose and the rate of sustained ROSC (n = 7) or survival (n = 6). Meta-analysis was not considered appropriate due to clinical heterogeneity. Riskof bias was moderate. All animal studies were randomized controlled trials with 8 and 52 (median = 27) piglets. ROSC was frequently achieved (>85%) with energy dose ranging from 2 to 7 J/kg (n = 7). The defibrillation threshold varied according to the body weight and appears to be higher in infant. Conclusion: Defibrillation energy doses and thresholds varied according to the body weight and trended higher for infants. No definitive association between initial defibrillation doses and the sustained ROSC or survival could be demonstrated. Clinicians should follow local consensus-based guidelines.
机译：目的：确定初始除颤能量剂量，其与持续循环（ROSC）的持续返回与心室蠕虫或无紫外线性心动过缓的儿科心脏骤停。方法：使用四个数据库（Prospero：CRD42016036734）进行系统审查。考虑了涉及外部除颤能量给药评估的儿科心脏骤停的人类研究和动物模型研究。主要结果是持续的ROSC。还评估生存和除颤诱导的并发症。结果：搜索策略确定了14,471名引文，其中审查了232个稿件。十个人和10个动物模型研究符合纳入标准。人类研究是前瞻性的（n = 6）或回顾性（n = 4）群组研究，包括11至266名患者（中位数= 46名患者）。持续的ROSC速率范围为0至61％（n = 7）。没有研究报告初始除颤能量剂量与持续ROSC（n = 7）或存活率（n = 6）之间的统计学上显着的关联。由于临床异质性，Meta分析不被适当。偏见风险适度。所有动物研究都是随机对照试验的8和52（中位数= 27）仔猪。经常达到ROSC（> 85％），能量剂量范围为2至7J / kg（n = 7）。除颤阈值根据体重而变化，婴儿似乎更高。结论：除颤能量和阈值根据体重而变化，婴儿的趋势趋势。可以证明初始除颤剂量和持续的ROSC或存活之间没有明确的关联。临床医生应遵循基于当地的共识的指导方针。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号