MicroRNA-21-5p as a novel therapeutic target for osteoarthritis

Wang Xiao-bo; Zhao Feng-chao; Yi Lin-hong; Tang Jin-long; Zhu Zheng-ya; Pang Yong; Chen Ye-shuai; Li Dong-ya; Guo Kai-jin; Zheng Xin

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MicroRNA-21-5p as a novel therapeutic target for osteoarthritis

机译：microRNA-21-5P作为骨关节炎的新疗法靶标

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Objective. Growing evidence indicates that microRNAs (miRNA) play a critical role in the pathogenesis of OA, and overexpressing or silencing miRNA expression in OA models can contribute to the development of miRNA-based therapeutics. The objective of this study was to determine whether intra-articular injection of miRNA can inhibit OA progression.

机译：客观的。日益增长的证据表明，微大RNA（miRNA）在OA的发病机制中发挥着关键作用，OA模型中的过表达或沉默的miRNA表达可以有助于MiRNA的治疗方法的发育。本研究的目的是判断特内注射miRNA是否可以抑制OA进展。

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来源
《Rheumatology》 |2019年第8期|共13页
作者
Wang Xiao-bo; Zhao Feng-chao; Yi Lin-hong; Tang Jin-long; Zhu Zheng-ya; Pang Yong; Chen Ye-shuai; Li Dong-ya; Guo Kai-jin; Zheng Xin;
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作者单位

Sun Yat Sen Univ Affiliated Hosp 1 Dept Orthopaed Guangzhou Guangdong Peoples R China;

Xuzhou Med Univ Affiliated Hosp Dept Orthopaed 99 Huaihai Rd West Xuzhou 221006 Jiangsu;

Xuzhou Med Univ Affiliated Hosp Dept Orthopaed 99 Huaihai Rd West Xuzhou 221006 Jiangsu;

Xuzhou Med Univ Affiliated Hosp Dept Orthopaed 99 Huaihai Rd West Xuzhou 221006 Jiangsu;

Xuzhou Med Univ Affiliated Hosp Dept Orthopaed 99 Huaihai Rd West Xuzhou 221006 Jiangsu;

Xuzhou Med Univ Affiliated Hosp Dept Orthopaed 99 Huaihai Rd West Xuzhou 221006 Jiangsu;

Xuzhou Med Univ Affiliated Hosp Dept Orthopaed 99 Huaihai Rd West Xuzhou 221006 Jiangsu;

Xuzhou Med Univ Affiliated Hosp Dept Orthopaed 99 Huaihai Rd West Xuzhou 221006 Jiangsu;

Xuzhou Med Univ Affiliated Hosp Dept Orthopaed 99 Huaihai Rd West Xuzhou 221006 Jiangsu;

Xuzhou Med Univ Affiliated Hosp Dept Orthopaed 99 Huaihai Rd West Xuzhou 221006 Jiangsu;

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原文格式 PDF
正文语种 eng
中图分类免疫性疾病;
关键词
osteoarthritis; antagomir-21-5p; miRNA-based therapeutics; FGF18;

机译：骨关节炎;antagomir-21-5p;基于miRNA的治疗方法;FGF18;

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专利

1. MicroRNA-21-5p as a novel therapeutic target for osteoarthritis [J] . Wang Xiao-bo, Zhao Feng-chao, Yi Lin-hong, Rheumatology . 2019,第8期

机译：microRNA-21-5P作为骨关节炎的新疗法靶标
2. Small extracellular vesicles in combination with sleep-related circRNA3503: A targeted therapeutic agent with injectable thermosensitive hydrogel to prevent osteoarthritis [J] . Shi-Cong Tao, Ji-Yan Huang, Yuan Gao, Bioactive Materials . 2021,第12期

机译：小细胞外囊与睡眠相关的CiRCRNA3503：靶向治疗剂，具有可注射热敏水凝胶，以防止骨关节炎
3. AMPK: implications in osteoarthritis and therapeutic targets [J] . Junjie Wang, Jiali Li, Deye Song, American Journal of Translational Research . 2020,第12期

机译：AMPK：对骨关节炎和治疗目标的影响
4. Preliminary Therapeutic Knee Band Development for Knee Osteoarthritis (KOA) Relief in the Elderly: A Pilot Study [C] . Zidan Gong, Rong Liu, Winnie Yu, International Conference on Applied Human Factors and Ergonomics . 2019

机译：老年人膝关节骨关节炎（KOA）救济的初步治疗膝关节：试验研究
5. Synovial Fibrosis in Osteoarthritis of the Knee: Mechanism of Development and Potential Therapeutic Targets [D] . Qadri, Marwa. 2021

机译：膝关节骨关节炎的滑膜纤维化：发展机制及潜在治疗目标
6. Control of the Autophagy Pathway in Osteoarthritis: Key Regulators Therapeutic Targets and Therapeutic Strategies [O] . Maria Teresa Valenti, Luca Dalle Carbonare, Donato Zipeto, 2021

机译：对骨关节炎的自噬途径控制：关键调节因子治疗目标和治疗策略
7. Control of the Autophagy Pathway in Osteoarthritis: Key Regulators, Therapeutic Targets and Therapeutic Strategies [O] . Maria Teresa Valenti, Luca Dalle Carbonare, Donato Zipeto, 2021

机译：对骨关节炎的自噬途径控制：关键调节因子，治疗目标和治疗策略
8. Intra-Articular Therapeutic Delivery for Post-Traumatic Osteoarthritis. [R] . Guldberg, R. E. 2017

机译：创伤后骨关节炎的关节内治疗。

MicroRNA-21-5p as a novel therapeutic target for osteoarthritis

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