Risk of tuberculosis in patients with chronic immune-mediated inflammatory diseases treated with biologics and tofacitinib: a systematic review and meta-analysis of randomized controlled trials and long-term extension studies.

Alejandro Souto; José Ramón Maneiro; Eva Salgado; Loreto Carmona; Juan J Gomez-Reino

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Risk of tuberculosis in patients with chronic immune-mediated inflammatory diseases treated with biologics and tofacitinib: a systematic review and meta-analysis of randomized controlled trials and long-term extension studies.

机译：慢性免疫介导的患者结核病风险，慢性免疫介导的生物学和TOFACITINIB治疗：随机对照试验和长期扩展研究进行了系统审查和荟萃分析。

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RCTs are not sensitive enough to assess the risk of reactivation of latent TB infection (LTBI). Disease, treatment and background TB rate are associated with different frequencies of active TB. The benefit/risk balance of preventing reactivation of LTBI in different backgrounds should be considered in clinical practice.

机译：RCTS不足以评估潜伏结核病感染（LTBI）的重新激活的风险。疾病，治疗和背景TB速率与不同的活性TB频率相关。在临床实践中应考虑预防不同背景下LTBI重新激活的效益/风险平衡。

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来源
《Rheumatology》 |2014年第10期|共14页
作者
Alejandro Souto; José Ramón Maneiro; Eva Salgado; Loreto Carmona; Juan J Gomez-Reino;
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作者单位

Rheumatology Unit Complejo Hospitalario de Santiago de Compostela IDIS Ramon Dominguez Santiago;

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原文格式 PDF
正文语种 eng
中图分类免疫性疾病;
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1. Risk of tuberculosis in patients with chronic immune-mediated inflammatory diseases treated with biologics and tofacitinib: a systematic review and meta-analysis of randomized controlled trials and long-term extension studies. [J] . Alejandro Souto, José Ramón Maneiro, Eva Salgado, Rheumatology . 2014,第10期

机译：用生物制剂和托法替尼治疗的慢性免疫介导的炎症性疾病患者的结核病风险：随机对照试验和长期延伸研究的系统评价和荟萃分析。
2. Effect of tofacitinib on cardiovascular events and all-cause mortality in patients with immune-mediated inflammatory diseases: a systematic review and meta-analysis of randomized controlled trials [J] . Wenhui Xie, Shiyu Xiao, Yanrong Huang, Therapeutic advances in musculoskeletal disease. . 2019,第12期

机译：Tofacitinib对免疫介导的炎症性疾病患者心血管事件和全因死亡率的影响：随机对照试验的系统审查和荟萃分析
3. Lipid Profile Changes in Patients With Chronic Inflammatory Arthritis Treated With Biologic Agents and Tofacitinib in Randomized Clinical Trials A Systematic Review and Meta-Analysis [J] . Souto Alejandro, Salgado Eva, Ramon Maneiro Jose, Arthritis & rheumatology. . 2015,第1期

机译：生物制剂和托法替尼治疗的慢性炎性关节炎患者的血脂谱变化在随机临床试验中的系统评价和荟萃分析
4. Stroke unit of integrative medicine for post stroke comorbid anxiety and depression: A systematic review and meta-analysis of 25 randomized controlled trials [C] . Lingfeng Zeng, Changrong Meng, Zhaohui Liang, IEEE International Conference on Bioinformatics and Biomedicine . 2014

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5. The Effects of Yoga on Cognitive Function in Neuropsychiatric Disorders: A Systematic Review and Meta-analysis of Randomized Controlled Trials [D] . Johnson, Tessa C. 2018

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机译：托法替尼对心血管事件和全因的影响免疫介导的炎性疾病患者的死亡率：系统的随机对照试验的回顾和荟萃分析
7. Risk of tuberculosis in patients with chronic immune-mediated inflammatory diseases treated with biologics and tofacitinib: a systematic review and meta-analysis of randomized controlled trials and long-term extension studies [O] . Alejandro Souto, José Ramón Maneiro, Eva Salgado, 2014

机译：慢性免疫介导的生物学和TOFACITIN患者结核病患者的风险：随机对照试验的系统审查和荟萃分析和长期扩展研究

Risk of tuberculosis in patients with chronic immune-mediated inflammatory diseases treated with biologics and tofacitinib: a systematic review and meta-analysis of randomized controlled trials and long-term extension studies.

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