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首页> 外文期刊>Rheumatology >A case of overlap syndrome successfully treated with tocilizumab: a hopeful treatment strategy for refractory dermatomyositis?
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A case of overlap syndrome successfully treated with tocilizumab: a hopeful treatment strategy for refractory dermatomyositis?

机译：用托运南瓜成功治疗重叠综合症的情况：难治性皮塔米肌炎的充满希望的治疗策略？

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Magnetoencephalographic (MEG) investigations of inter-regional amplitude correlations have yielded new insights into the organization and neurophysiology of resting-state networks (RSNs) first identified using fMRI. Inter-regional MEG amplitude correlations in adult RSNs have been shown to be most prominent in alpha and beta frequency ranges and to express strong congruence with RSN topologies found using fMRI. Despite such advances, little is known about how oscillatory connectivity in RSNs develops throughout childhood and adolescence. This study used a novel fMRI-guided MEG approach to investigate the maturation of resting-state amplitude correlations in physiologically relevant frequency ranges within and among six RSNs in 59 participants, aged 6-34 years. We report age-related increases in inter-regional amplitude correlations that were largest in alpha and beta frequency bands. In contrast to fMRI reports, these changes were observed both within and between the various RSNs analyzed. Our results provide the first evidence of developmental changes in spontaneous neurophysiological connectivity in source-resolved RSNs, which indicate increasing integration within and among intrinsic functional brain networks throughout childhood, adolescence, and early adulthood.
机译：磁性肺（MEG）对区域间振幅相关性的研究产生了新的见解，该洞察静态网络（RSNS）的组织和神经生理学首次使用FMRI识别。成人RSNS中的区域间MEG幅度相关性在Alpha和Beta频率范围内最为突出，并表达使用FMRI发现的RSN拓扑的强烈一致性。尽管存在此类进步，但对于RSNS在整个童年和青春期发展的振荡连接知之甚少。本研究采用了一种新型的FMRI引导的MEG方法来研究59名参与者内部的生理相关频率范围内的生理相关频率范围内的休息状态幅度相关性，以6-34岁。我们报告了在α和β频带中最大的区域间振幅相关性的年龄相关的增加。与FMRI报告相比，在分析的各种RSN内和之间观察到这些变化。我们的结果提供了源自解决RSNS中自发性神经生理连接中发育变化的第一种证据，这表明整个童年，青春期和成年早期内在功能性脑网络内部和内在功能性脑网络中的一体化。

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