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首页> 外文期刊>Rheumatology international. >Renal flare in class V lupus nephritis: increased risk in patients with tubulointerstitial lesions
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Renal flare in class V lupus nephritis: increased risk in patients with tubulointerstitial lesions

机译：V型狼疮肾炎中的肾耀斑：跨细胞间病变患者的风险增加

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摘要

The objective of this study is to investigate the risk factors of renal flare in patients with membranous lupus nephritis (class V lupus nephritis). Biopsy-proven pure membranous lupus nephritis patients diagnosed between January 1997 and September 2017 were studied. We assessed and compared the clinical and pathological parameters between patients who experienced renal flare and those who did not. To identify risk factors of renal flare, multivariable Cox proportional hazard regression analysis was performed. Out of the 53 patients with pure membranous lupus nephritis, 17 patients (32.1 %) experienced renal flare during a median follow-up of 121.5 months (range 44.4-196.9). Patients who experienced renal flare had significantly higher proportion of tubulointerstitial inflammation (76.5% vs. 36.1%, p = 0.006) and tubular atrophy/interstitial fibrosis (70.6% vs. 27.8%, p = 0.003) at baseline. In multivariable Cox proportional hazard regression analysis, the presence of tubulointerstitial inflammation [adjusted hazard ratio (HR) 5.532, 95% confidence interval (Cl) 1.722-17.776, p = 0.004] and tubular atrophy/interstitial fibrosis (adjusted HR 4.328, 95% Cl 1.450-12.916, p= 0.009) at baseline was significantly associated with increased risk of renal flare. The presence of tubulointerstitial inflammation and tubular atrophy/interstitial fibrosis is associated with increased risk of renal flare in patients with membranous lupus nephritis.
机译：本研究的目的是探讨膜狼疮肾炎患者肾耀斑的危险因素（V型狼疮肾炎）。研究了1997年1月至2017年1月至2017年9月诊断的活组织检查证明的纯膜狼疮肾炎。我们评估并比较了经历肾耀斑的患者和那些没有的患者之间的临床和病理参数。为了确定肾耀斑的危险因素，进行多变量的Cox比例危害回归分析。在53例纯膜狼疮肾炎患者中，17名患者（32.1％）在121.5个月的中间随访期间经验丰富的肾眩光（范围44.4-196.9）。经历肾爆炸的患者显着较高的微管间炎症（76.5％，P = 0.006）和管状萎缩/间质纤维化（70.6％vs.27.8％，P = 0.003）。在多变量的Cox比例危害回归分析中，对微管间炎症的存在[调整后危险比（HR）5.532,95％置信区间（CL）1.722-17.776，P = 0.004]和管状萎缩/间质纤维化（调整后的HR 4.328，95％基线Cl 1.450-12.916，p = 0.009）与肾耀斑的风险增加显着相关。细胞间炎症和管状萎缩/间质纤维化的存在与膜狼疮肾炎患者肾峰的风险增加有关。

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