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首页> 外文期刊>BJU international >Patients with prostate cancer continue to have excess mortality up to 15 years after diagnosis
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Patients with prostate cancer continue to have excess mortality up to 15 years after diagnosis

机译：前列腺癌患者在诊断后长达15年的死亡率仍然很高

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Objective To estimate the population-based conditional 5-year relative survival rates for patients with prostate cancer (PCa). Patients and Methods All 98 672 patients, aged 45-89 years, diagnosed in the Netherlands with PCa (clinical T stage 1-4) in the period 1989-2008 were selected from the Netherlands Cancer Registry and followed up until 2010. The conditional 5-year relative survival rate was estimated for every subsequent year of survival up to 15 years after diagnosis. Results The conditional 5-year relative survival rate decreased with survival time from diagnosis. Excess mortality (conditional 5-year relative survival rate <95%) for patients with clinical T1 stage only became manifest 5 years after diagnosis and increased to almost 10% after 10 years. Patients with more advanced disease (cT2-cT4) were found to have an excess mortality rate of 6-12% at diagnosis, which increased to 15-22% after 10 years. Excess mortality occurred earlier for the older age groups. The 5-year relative survival rate at diagnosis was <90% for all age groups of patients with cT3/cT4 disease and excess mortality for this group increased to >20% for those who had already survived for 5 years since diagnosis. Conclusions Patients with PCa were found to have excess mortality within 10 years of diagnosis. Excess mortality was found at an earlier timepoint for patients with a more advanced stage and for older age groups. Quantitative insight into conditional survival is useful for caregivers to help plan optimum cancer treatment and surveillance and to inform patients about their actual prognosis during follow-up, taking the current condition of the patient into account.
机译：目的评估以人群为基础的前列腺癌（PCa）患者5年相对生存率。患者和方法1989-2008年期间在荷兰诊断为PCa（临床T期1-4）的所有98672名年龄在45-89岁的患者均选自荷兰癌症登记处，并随访至2010年。有条件的5在诊断后直至15年的每一后续生存年中，均需估算15年相对生存率。结果从诊断开始，有条件的5年相对生存率随生存时间而降低。临床T1期患者的超额死亡率（有条件的5年相对生存率<95％）仅在诊断后5年才显现出来，并在10年后增加到近10％。发现患有更晚期疾病（cT2-cT4）的患者在诊断时有6-12％的过高死亡率，在10年后增加到15-22％。较高的死亡率发生在较早的年龄组。在所有年龄段的cT3 / cT4疾病患者中，诊断时的5年相对存活率<90％，而自诊断以来已经存活5年的患者，该组的超额死亡率增加到> 20％。结论发现PCa患者在诊断后10年内死亡率过高。对于处于晚期阶段的患者和年龄较大的人群，在较早的时间点发现过高的死亡率。对条件生存的定量了解对于护理人员有助于计划最佳的癌症治疗和监测，并在考虑到患者当前病情的情况下，在随访期间告知患者其实际预后。

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