Synthesis and Characterization of Colistin Loaded Nanoparticles Used to Combat Multi-drug Resistant Microorganisms

Ichim Daniela Luminita; Duceac Letitia Doina; Marcu Constantin; Iordache Alin Constantin; Ciomaga Irina Mihaela; Luca Alina Costina; Goroftei Elena Roxana Bogdan; Mitrea Geta; Damir Daniela; Stafie Liviu

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Synthesis and Characterization of Colistin Loaded Nanoparticles Used to Combat Multi-drug Resistant Microorganisms

机译：Colistin负载纳米粒子的合成与表征用于打击多药物抗性微生物的纳米粒子

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Some infectious agents frequently act on human body. Multi-drug resistant microorganisms (MDR) develop the capacity to stabilize biofilms. The use of antimicrobials loaded nanoparticles can defeat antibiotic resistance mechanism. The major aim of this study was the synthesis and physico-chemical characterization of Colistin molecules intercalated nanoparticles in order to enhance antibiotic efficacy against multi-drug resistant microorganisms. Advanced characterization techniques were used to analyze new nanostructures containing antibiotics in order to improve antimicrobial efficacy of the free drug. Nano-encapsulated Colistin is presumed to be more efficient in the eradication of severe infections caused by MDR.

机译：一些传染病经常对人体行动。多毒性微生物（MDR）显影稳定生物膜的能力。使用抗微生物的纳米颗粒可以脱抗生素抗性机制。本研究的主要目的是Colistin分子插层纳米粒子的合成和物理化学表征，以提高针对多毒性微生物的抗生素功效。使用高级表征技术来分析含有抗生素的新纳米结构，以提高游离药物的抗微生物功效。纳米封装的Colistin被认为在消除MDR引起的严重感染方面更有效。

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来源
《Revista de Chimie》 |2019年第10期|共4页
作者
Ichim Daniela Luminita; Duceac Letitia Doina; Marcu Constantin; Iordache Alin Constantin; Ciomaga Irina Mihaela; Luca Alina Costina; Goroftei Elena Roxana Bogdan; Mitrea Geta; Damir Daniela; Stafie Liviu;
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作者单位

Apollonia Univ Iasi Fac Med 2 Muzicii Str Iasi Romania;

Apollonia Univ Iasi Fac Med 2 Muzicii Str Iasi Romania;

Univ Dunarea de Jos Fac Med &

Pharm 47 Domneasca Str Galati 800008 Romania;

Grigore T Popa Univ Med &

Pharm Iasi 16 Univ Str Iasi 700115 Romania;

Grigore T Popa Univ Med &

Pharm Iasi 16 Univ Str Iasi 700115 Romania;

Grigore T Popa Univ Med &

Pharm Iasi 16 Univ Str Iasi 700115 Romania;

Univ Dunarea de Jos Fac Med &

Pharm 47 Domneasca Str Galati 800008 Romania;

Univ Dunarea de Jos Fac Med &

Pharm 47 Domneasca Str Galati 800008 Romania;

Grigore T Popa Univ Med &

Pharm Iasi 16 Univ Str Iasi 700115 Romania;

Apollonia Univ Iasi Fac Med 2 Muzicii Str Iasi Romania;

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原文格式 PDF
正文语种 eng
中图分类化学;
关键词
nanoparticles; Colistin; infection; sepsis; pediatrics; epidemiology; neurosurgery; cardiology; pulmonology;

机译：纳米粒子;菌条;感染;败血症;儿科;流行病学;神经外科;心脏病学;肺动脉;

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1. Synthesis and Characterization of Colistin Loaded Nanoparticles Used to Combat Multi-drug Resistant Microorganisms [J] . Ichim Daniela Luminita, Duceac Letitia Doina, Marcu Constantin, Revista de Chimie . 2019,第10期

机译：Colistin负载纳米粒子的合成与表征用于打击多药物抗性微生物的纳米粒子
2. Drug resistance reversal activity of anticancer drug loaded solid lipid nanoparticles in multi-drug resistant cancer cells [J] . Miao J., Du Y.-Z., Yuan H., Colloids and Surfaces, B. Biointerfaces . 2013,第Null期

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3. Comparative Study on Photodynamic Activation of Ortho-Toluidine Blue and Methylene Blue Loaded Mesoporous Silica Nanoparticles Against Resistant Microorganisms | Bentham Science [J] . Ashka Amina, Deepali V. Kaduskar Recent patents on drug delivery & formulation . 2018,第3期

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4. Synthesis and Characterization of Biogenic Selenium Nanoparticles with Antimicrobial Properties Made by Staphylococcus aureus, Methicillin-resistant Staphylococcus aureus (MRSA), Escherichia coli and Pseudomonas aeruginosa. [C] . David Medina, Thomas J. Webster Society for Biomaterials annual meeting and exposition . 2018

机译：金黄色葡萄球菌，耐甲氧西林金黄色葡萄球菌（MRSA），大肠杆菌和铜绿假单胞菌制成的具有抗菌特性的生物硒纳米粒子的合成与表征。
5. Synthesis and Characterization of BSA Conjugated Silver Nanoparticles (Ag/BSA Nanoparticles) and Evaluation of Biological Properties of Ag/BSA Nanoparticles and Ag/BSA Nanoparticles Loaded Poly(hydroxy butyrate valerate) PHBV Films. [D] . Ambaye, Almaz. 2015

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7. Bio-nanobactericides: an emanating class of nanoparticles towards combating multi-drug resistant pathogens [O] . Syed Baker, Olga V. Perianova 2019

机译：生物纳米杆菌剂：一种朝向打击多药物抗性病原体的纳米颗粒的爆炸类别

Synthesis and Characterization of Colistin Loaded Nanoparticles Used to Combat Multi-drug Resistant Microorganisms

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