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Occupational cannabis exposure and allergy risks

机译：职业大麻暴露和过敏风险

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Cannabis allergy has mainly been described following recreational use but some cases also point to cannabis sensitisation as a result of occupational exposure. As a consequence, little is known on the prevalence and clinical phenotype of occupational cannabis allergy. Therefore, this study aims to explore the allergy-associated health risks of occupational cannabis exposure in Belgian police force personnel.81 participants, active in the police force, reporting regular occupational cannabis exposure during the past 12?months, were included. History was combined with a standardised questionnaire on allergies and cannabis exposure.Basophil activation tests (BATs) with a crude cannabis extract and rCan s 3 were performed. In addition, specific (s)IgE rCan s 3 as well as sIgE to house dust mite, six pollen and three mould allergens were quantified.Although 42% of the participants reported respiratory and/or cutaneous symptoms on occupational cannabis exposure, all cannabis diagnostics were entirely negative, except one symptomatic case demonstrating a borderline result. Furthermore, there is no significant difference between the groups with and without symptoms on cannabis exposure in terms of allergenic sensitisations.The origins of the reported respiratory and cutaneous symptoms during cannabis exposure remain elusive but are probably due to non-immune reactions. It should be noted that the study was volunteer-based possibly reflecting an excessive number of symptomatic individuals. Nevertheless, as only one participant reported using fully protective gear, much improvement is needed for reducing the number of symptoms reported on duty, independent of their origin.
机译：大麻过敏主要是在娱乐使用之后描述的，但有些情况也指向职业暴露的大麻敏化。因此，对职业大麻过敏的患病率和临床表型知之甚少。因此，本研究旨在探讨比利时警察部队人员的职业大麻暴露的过敏相关健康风险.81参与者，积极参与警察，在过去12个月内报告定期职业大麻暴露。历史与过敏和大麻暴露的标准化问卷相结合。具有粗大麻提取物和RCAN S 3的基础粒细胞激活试验（蝙蝠）。此外，定量了特定的IgE RCAN S 3以及房屋粉尘的Sige，六种花粉和三种模具过敏原。虽然42％的参与者报告了职业大麻暴露的呼吸系统和/或皮肤症状，但所有大麻诊断完全是负面的，除了一个表现出边界结果的一个有症的案例。此外，在过敏性敏感性脑梗死方面，在大麻暴露中没有症状的群体之间没有显着差异。报告的呼吸道和皮肤症状的起源仍然是难以捉摸的，但可能是由于非免疫反应。应该指出的是，该研究是基于志愿者的，可能反映了过量的症状性质。尽管如此，只有一个参与者报告使用完全保护齿轮的参与者，还需要更好的改进来减少有关职责的症状数量，与其起源无关。

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