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首页> 外文期刊>Occupational and environmental medicine >Bladder cancer and occupational exposure to metalworking fluid mist: a counter-matched case–control study in French steel-producing factories
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Bladder cancer and occupational exposure to metalworking fluid mist: a counter-matched case–control study in French steel-producing factories

机译：膀胱癌和职业接触金属加工液体雾：法国钢铁工厂的反匹配病例对照研究

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To assess the relationship between occupational exposure to metalworking fluids (MWFs) in the steel-producing industry and bladder cancer incidence.A nested case–control study on bladder cancer was set up in a cohort of workers from six French steel-producing factories. Three controls were randomly selected for each incident bladder cancer case diagnosed from 2006 to 2012. Controls were matched to cases on age at diagnosis and counter-matched on a surrogate measure of exposure to MWFs derived from a job-exposure matrix. Cases (n=84) and controls (n=251) were face-to-face interviewed. Experts assessed occupational exposure to MWFs (straight, soluble and synthetic) using questionnaires and reports from factory visits. Occupational exposures were based on three metrics: duration, frequency-weighted duration and cumulative exposure index. Conditional multiple logistic regressions were used to determine ORs and 95% CIs, taking non-occupational and occupational exposure into account.In the 25 years before diagnosis, ORs increased significantly with duration of exposure to straight MWFs (OR=1.13 (1.02–1.25)) and increased with frequency-weighted duration of exposure to straight MWFs (OR=1.44 (0.97–2.14)). These results remained valid after adjusting for duration of smoking, average number of cigarettes smoked per day, time since smoking cessation and exposure to polycyclic aromatic hydrocarbons (PAHs). ORs also increased with soluble MWFs but not significantly. No significant association was found with older exposures to MWFs or with exposure to synthetic MWFs.The increased risk of bladder cancer observed among workers exposed to straight MWFs and to a lesser extent to soluble MWFs may be explained by the presence of carcinogens (such as PAH) in mineral oils component of straight and soluble oils. Prevention therefore remains necessary in sectors using MWFs.
机译：为了评估施工产业和膀胱癌发生率的职业暴露与金属加工液（MWF）之间的关系。患有六个法国炼钢厂的工人队伍队伍建立了患有膀胱癌的嵌套病例对照研究。为从2006年至2012年诊断出的每个事件膀胱癌病例随机选择三种对照。对照与年龄在诊断年龄的病例和反匹配对来自职业曝光矩阵衍生的MWF的替代衡量标准。案例（n = 84）和控制（n = 251）面对面接受采访。专家评估了使用问卷调查和从工厂访问的报告的职业暴露于MWFS（直接，可溶性和合成）。职业暴露是基于三个度量：持续时间，频率加权持续时间和累积曝光指数。有条件的多重逻辑回归用于确定或95％CI，以危害非职业和职业暴露在诊断前25年，或者在直线MWF暴露的持续时间显着增加（或= 1.13（1.02-1.25） ）通过接触直线MWF的频率加权持续时间（或= 1.44（0.97-2.14）而增加。在调整吸烟持续时间后，这些结果保持有效，每天吸烟的平均卷烟数量，自吸食和暴露于多环芳烃（PAH）以来的时间。或者也随着可溶性MWF而且没有显着增加。没有显着的关联对于MWF，或接触合成MWFS。在暴露于直MWF的工人和对可溶性MWF的较小程度上观察到的膀胱癌的风险增加可能通过致癌物质（例如PAH ）在直链和可溶性油的矿物油组分中。因此，预防仍然在使用MWF的部门中仍然是必要的。

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