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首页> 外文期刊>Occupational and environmental medicine >Heart rate variability and peripheral nerve conduction velocity in relation to blood lead in newly hired lead workers
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Heart rate variability and peripheral nerve conduction velocity in relation to blood lead in newly hired lead workers

机译：心率变异性和外周神经传导速度与血铅相关的新雇用铅工人

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Objectives Previous studies relating nervous activity to blood lead (BL) levels have limited relevance, because over time environmental and occupational exposure substantially dropped. We investigated the association of heart rate variability (HRV) and median nerve conduction velocity (NCV) with BL using the baseline measurements collected in the Study for Promotion of Health in Recycling Lead (NCT02243904). Methods I n 328 newly hired men (mean age 28.3 years; participation rate 82.7%), we derived HRV measures (power expressed in normalised units (nu) in the high-frequency (HF) and low-frequency (LF) domains, and LF/HF) prior to long-term occupational lead exposure. Five-minute ECG recordings, obtained in the supine and standing positions, were analysed by Fourier transform or autoregressive modelling, using Cardiax software. Motor NCV was measured at the median nerve by a handheld device (Brevio Nerve Conduction Monitoring System, NeuMed, West Trenton, NJ, USA). BL was determined by inductively coupled plasma mass spectrometry. Results Mean BL was 4.54 mu g/dL (IQR 2.60-8.90 mu g/ dL). Mean supine and standing values of LF, HF and LF/ HF were 50.5 and 21.1 nu and 2.63, and 59.7 and 10.9 nu and 6.31, respectively. Orthostatic stress decreased HF and increased LF (p< 0.001). NCV averaged 3.74 m/s. Analyses across thirds of the BL distribution and multivariable-adjusted regression analyses failed to demonstrate any association of HRV or NCV with BL. Conclusions A t the exposure levels observed in our study, autonomous nervous activity and NCV were not associated with BL.
机译：目的以往的研究与血铅（BL）水平相关的神经活动有限相关性，因为随着时间的推移环境和职业暴露大幅下降。我们使用研究中收集的基线测量来研究心率变异性（HRV）和中位神经传导速度（NCV）的关联，用于促进回收铅的健康（NCT02243904）。方法I N 328新雇用的男性（平均年龄28.3岁;参与率82.7％），我们衍生出HRV措施（以正常化单位（Nu）中的高频（HF）和低频（LF）域，以及LF / HF）在长期职业铅暴露之前。使用Cardiax软件通过傅里叶变换或自动评级建模分析了五分钟的ECG录像，在仰卧和站立位置获得。通过手持设备（Brevio神经传导监测系统，Neumed，West Trenton，NJ，USA）在中位神经测量电机NCV。通过电感耦合等离子体质谱法测定BL。结果平均值BL为4.54μg/ dL（IQR 2.60-8.90 mu g / dl）。 LF，HF和LF / HF的平均值和静止值分别为50.5和21.1元，分别为2.63和59.7和10.9元和6.31。原位应激降低HF并增加LF（p <0.001）。 NCV平均为3.74米/秒。 BL分布和多变量调整后回归分析的三分之二的分析未能证明HRV或NCV的任何关联与BL。结论在我们的研究中观察到的暴露水平，自主神经活性和NCV与BL无关。

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