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Severe antithrombin deficiency in pregnancy: Achieving adequate anticoagulation

机译:怀孕的严重抗凝血酶缺乏:实现足够的抗凝

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摘要

Antithrombin deficiency is identified as one of the most potent risk factors for venous thromboembolism during pregnancy. Therapeutic low molecular weight heparin is recommended, but it can be difficult to attain sufficient anticoagulation since low molecular weight heparin requires antithrombin to exert its anticoagulant effect. We carried out a multicentre case-series assessing the dose of low molecular weight heparin required to achieve therapeutic anti-activated factor X levels in pregnant women with antithrombin deficiency. We assessed 27 pregnancies in 18 women with severe antithrombin deficiency, which we defined as an antithrombin level of <0.55?IU/ml (with or without prior venous thromboembolism) or an antithrombin level?
机译:抗凝血酶缺乏被鉴定为怀孕期间静脉血栓栓塞最有效的危险因素之一。建议治疗低分子量肝素,但由于低分子量肝素需要抗凝血蛋白,因此难以获得足够的抗凝血以施加抗凝血效果。我们进行了一种多中心病例系列评估,评估低分子量肝素的剂量,以实现具有抗凝血酶缺乏的孕妇治疗抗激活因子X水平。我们评估了18名患有严重抗凝血酶缺乏的患者的27名怀孕,我们定义为<0.55?Iu / ml(有或没有现有的静脉血栓栓塞)或抗凝血酶水平的抗凝血酶水平?<?0.8?IU / ml和个人历史和个人历史静脉血栓栓塞。我们的数据说明了对高剂量的低分子量肝素的需要,以实现治疗性抗激活因子X水平(平均为20,220〜IU /天)。所有妊娠结束于活产(不包括一个选修终止),尽管宫内生长限制发生在五(18%)。

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